The aim of this pilot study was to test the hypotheses that a) WMHs would be a biological marker in South Indian patients who present with either cognitive impairment, dementia or depression and b) presence of WMHs would be related to other blood biochemical markers. A significant positive correlation was present between temporal WMHs and increased homocysteine levels. A significant inverse correlation was obtained between MMSE scores and frontal caps. Association between temporal WMHs and elevated plasma homocysteine levels implies that this can serve as a biological marker for cognitive impairment and possibly for therapy.

中文翻译：

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WMH和同型半胱氨酸水平可作为认知障碍的候选生物标志物

这项前瞻性研究的目的是检验以下假设：a）WMH在存在认知障碍，痴呆或抑郁症的南印度患者中将是一种生物标记，并且b）WMH的存在与其他血液生化标记有关。颞叶WMH与同型半胱氨酸水平升高之间存在显着正相关。MMSE得分和额顶之间存在显着的反相关。暂时性WMH与血浆同型半胱氨酸水平升高之间的关联意味着这可以作为认知障碍和治疗方法的生物学标记。