Although animal research and some rare human case reports suggest that lesions of the dorsal pons yield saccadic and smooth pursuit eye movement deficits, little is known about the functional topology of the human pontine nuclei (PN) and whether limb movements are similarly affected as eye movements. Saccadic as well as SP eye and pointing movements were measured in six patients with lesions in the PN region. Five patients of the six exhibited dysmetric saccades, whilst smooth pursuit gain was reduced in four. Pontine lesions also alter the relationship between amplitude, velocity, and velocity skewness of saccadic eye movements. Limb movement trajectories were more curved in four patients. The results suggest that the lesions impair a general calibration mechanism that uses the parallel fiber-Purkinjecell synapse in the cerebellar cortex to adjust the timing of muscle innervation in visually guided oculomotor as well as limb movement tasks.

中文翻译：

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庞廷病变损害视觉引导的眼睛和手部动作

尽管动物研究和一些罕见的人类病例报告表明，背桥的病变会引起眼球顺滑和顺滑追赶，但对人桥脑核（PN）的功能拓扑以及肢体运动是否与眼球运动同样受到影响的知之甚少。测量了6名PN区有病变的患者的眼跳，SP眼和指向运动。六个病人中有五个病人表现为扫视困难，而四个人的顺畅追逐增益却降低了。桥状病变还改变了眼跳的幅度，速度和速度偏度之间的关系。四名患者的肢体运动轨迹更为弯曲。