High intensity interval exercise (HIIE) improves aerobic fitness with decreased exercise time compared to moderate continuous exercise. A gap in knowledge exists regarding the effects of HIIE on cerebrovascular function such as cerebral blood velocity and autoregulation. The objective of this systematic review was to ascertain the effect of HIIE on cerebrovascular function in healthy individuals. We searched PubMed and the Cumulative Index to Nursing and Allied Health Literature databases with apriori key words. We followed the Preferred Reporting Items for Systematic Reviews. Twenty articles were screened and thirteen articles were excluded due to not meeting the apriori inclusion criteria. Seven articles were reviewed via the modified Sackett's quality evaluation. Outcomes included middle cerebral artery blood velocity (MCAv) (n=4), dynamic cerebral autoregulation (dCA) (n=2), cerebral de/oxygenated hemoglobin (n=2), cerebrovascular reactivity to carbon dioxide (CO₂) (n=2) and cerebrovascular conductance/resistance index (n=1). Quality review was moderate with 3/7 to 5/7 quality criteria met. HIIE acutely lowered exercise MCAv compared to moderate intensity. HIIE decreased dCA phase following acute and chronic exercise compared to rest. HIIE acutely increased de/oxygenated hemoglobin compared to rest. HIIE acutely decreased cerebrovascular reactivity to higher CO₂ compared to rest and moderate intensity. The acute and chronic effects of HIIE on cerebrovascular function vary depending on the outcomes measured. Therefore, future research is needed to confirm the effects of HIIE on cerebrovascular function in healthy individuals and better understand the effects in individuals with chronic conditions. In order to conduct rigorous systematic reviews in the future, we recommend assessing MCAv, dCA and CO₂ reactivity during and post HIIE.

中文翻译：

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大强度间歇运动对脑血管功能的影响：系统评价

与中等程度的连续运动相比，高强度间歇运动（HIIE）可以改善有氧运动，并减少运动时间。关于HIIE对脑血管功能（如脑血流速度和自动调节）的影响，知识方面存在差距。本系统综述的目的是确定HIIE对健康个体脑血管功能的影响。我们使用先验关键词搜索了PubMed和《护理及相关健康文献》的累积索引。我们遵循了系统评价的首选报告项目。由于不符合先验纳入标准，筛选了20篇文章，排除了13篇文章。通过修改后的Sackett的质量评估对七篇文章进行了审查。结果包括大脑中动脉血流速度（MCAv）（n = 4），₂）（n = 2）和脑血管电导/阻力指数（n = 1）。质量审核为中度，符合3/7至5/7的质量标准。与中等强度相比，HIIE可使运动MCAv急剧降低。与休息相比，HIIE减少了急性和慢性运动后的dCA期。与休息相比，HIIE的脱氧合氧合血红蛋白急剧增加。HIIE对高CO ₂急性降低了脑血管反应性相比休息和中等强度。HIIE对脑血管功能的急性和慢性影响取决于测量的结果。因此，需要进一步的研究来确认HIIE对健康个体脑血管功能的影响，并更好地了解慢性病个体的影响。为了将来进行严格的系统审查，我们建议在HIIE期间和之后评估MCAv，dCA和CO ₂反应性。