当前位置: X-MOL 学术medRxiv. Neurol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Steroid-responsive encephalitis in Covid-19 disease
medRxiv - Neurology Pub Date : 2020-05-14 , DOI: 10.1101/2020.04.12.20062646
Andrea Pilotto , Silvia Odolini , Stefano Masciocchi S , Agnese Comelli , Irene Volonghi , Stefano Gazzina , Sara Nocivelli , Alessandro Pezzini , Emanuele Focà , Arnaldo Caruso , Matilde Leonardi , Maria Pia Pasolini , Roberto Gasparotti R , Francesco Castelli F , Nicholas J. Ashton , Kaj Blennow , Henrik Zetterberg , Alessandro Padovani

SARS-CoV-2 infection has the potential for targeting central nervous system and several neurological symptoms have been described in patients with severe respiratory distress. Here we described the case of an otherwise healthy 60-year old subject with SARS-CoV-2 infection but only mild respiratory abnormalities who developed severe progressive encephalopathy associated with mild pleocytosis and hyperproteinorrachia. MRI was negative whereas EEG showed theta waves on the anterior brain regions. Serum and CSF analyses excluded other known infectious or autoimmune disorders. The patient dramatically improved after high-doses steroid treatment suggesting an inflammatory-mediated brain involvement related to SARS-CoV-2 infection

中文翻译:

Covid-19病中类固醇反应性脑炎

SARS-CoV-2感染具有靶向中枢神经系统的潜力,严重呼吸窘迫患者已描述了几种神经系统症状。在这里,我们描述了一个原本健康的60岁受试者,患有SARS-CoV-2感染,但只有轻度呼吸道异常的情况,该异常会发展为与轻度胸膜增多症和蛋白尿过多症相关的严重进行性脑病。MRI阴性,而EEG在前脑区域显示theta波。血清和脑脊液分析排除了其他已知的感染性或自身免疫性疾病。大剂量类固醇治疗后患者显着改善,表明与SARS-CoV-2感染有关的炎症介导的脑受累
更新日期:2020-05-14
down
wechat
bug