Green plants on the earth have evolved intricate mechanisms to acclimatize to and utilize sunlight. In Arabidopsis, light signals are perceived by photoreceptors and transmitted through divergent but overlapping signaling networks to modulate plant photomorphogenic development. COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) was first cloned as a central repressor of photomorphogenesis in higher plants and has been extensively studied for over 30 years. It acts as a RING E3 ubiquitin ligase downstream of multiple photoreceptors to target key light-signaling regulators for degradation, primarily as part of large protein complexes. The mammalian counterpart of COP1 is a pluripotent regulator of tumorigenesis and metabolism. A great deal of information on COP1 has been derived from whole-genome sequencing and functional studies in lower green plants, which enables us to illustrate its evolutionary history. Here, we review the current understanding about COP1, with a focus on the conservation and functional diversification of COP1 and its signaling partners in different taxonomic clades.

地球上的绿色植物进化出复杂的机制来适应和利用阳光。在 拟南芥中，光信号被光感受器感知并通过发散但重叠的信号网络传输以调节植物光形态发育。COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) 首先被克隆为高等植物光形态发生的中心抑制因子，并已被广泛研究了 30 多年。它充当多个光感受器下游的 RING E3 泛素连接酶，以靶向关键的光信号调节剂进行降解，主要作为大蛋白质复合物的一部分。COP1 的哺乳动物对应物是肿瘤发生和代谢的多能调节剂。COP1 的大量信息来自低等绿色植物的全基因组测序和功能研究，这使我们能够说明其进化历史。在这里，我们回顾一下目前对 COP1 的理解，