Abstract Metal–organic frameworks (MOFs) are permanently microporous materials. MOFs have become promising candidates as drug delivery hosts because of high specific surface area. In this work, we control preparation of a new core–shell microsphere NaYF4:Yb,Er@NaYF4:Nd@MIL-53 by layer-by-layer self-assembly method. Here upconverting fluorescent nanoparticles (UCNPs) NaYF4:Yb,Er@NaYF4:Nd has potential for bioimaging due to excellent NIR optical property. MIL-53 as a drug carrier for DOX delivery. Folic acid as targeting agent is encapsulated into the above core-shell structured to form new nanocomposite (UCNPs@ MIL-53/FA). We have found that the new core–shell nanocomposites are nontoxic toward human cervix adenocarcinoma (HeLa) and can simultaneously achieve targeted therapy and drug delivery are used for the treatment of cancer. This result is expected to provide new ideas and perspectives for the treatment of cancer of the tumor.

中文翻译：

---

用于靶向和药物递送的核-壳上转换纳米颗粒@金属-有机框架纳米探针

摘要 金属有机框架 (MOF) 是永久性微孔材料。由于高比表面积，MOFs 已成为有希望的候选药物递送宿主。在这项工作中，我们通过逐层自组装方法控制了一种新的核壳微球 NaYF4:Yb,Er@NaYF4:Nd@MIL-53 的制备。这里上转换荧光纳米粒子 (UCNPs) NaYF4:Yb,Er@NaYF4:Nd 由于出色的 NIR 光学特性而具有用于生物成像的潜力。MIL-53 作为 DOX 递送的药物载体。作为靶向剂的叶酸被封装在上述核壳结构中形成新的纳米复合材料（UCNPs@MIL-53/FA）。我们发现新的核壳纳米复合材料对人宫颈腺癌（HeLa）无毒，可以同时实现靶向治疗和药物递送用于癌症的治疗。