Summary Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 cells. AVC suppressed the hypoxia-induced increase in COX-2 protein levels and promoter activity. We also observed that the effects of AVC were reversed by a SIRT1 inhibitor, indicating that the inhibitory effects of AVC on hypoxia-induced COX-2 expression are mediated by SIRT1. Therefore, AVC inhibits the hypoxic induction of COX-2 expression via SIRT1 activation. Our results suggest that AVC could be beneficial for preventing lung inflammation under hypoxia.

中文翻译：

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Avenanthramide C通过非小细胞肺癌细胞中的sirtuin1激活抑制缺氧诱导的环氧合酶2表达

总结 Avenanthramide C (AVC) 主要存在于燕麦中，通过降低抗炎细胞因子水平来介导抗炎活性。本研究调查了 AVC 对 A549 细胞中缺氧诱导的环氧合酶-2 (COX-2) 表达的影响。AVC 抑制缺氧诱导的 COX-2 蛋白水平和启动子活性的增加。我们还观察到 AVC 的作用被 SIRT1 抑制剂逆转，表明 AVC 对缺氧诱导的 COX-2 表达的抑制作用是由 SIRT1 介导的。因此，AVC 通过 SIRT1 激活抑制 COX-2 表达的缺氧诱导。我们的结果表明 AVC 可能有益于预防缺氧条件下的肺部炎症。