This prospective study of HIV-positive Kenyan women in serodiscordant couples examined relationships between psychosocial factors, viral suppression, and condomless sex. Participants were screened for alcohol use disorders and intimate partner violence (IPV) annually and depressive symptoms every 6 months. Prostate specific antigen (PSA) detection was used as a marker for condomless sex. A total of 151 participants contributed 349 person-years of follow-up. Hazardous/harmful alcohol use was associated with increased risk of detecting PSA in vaginal secretions (aRR 1.99, 95%CI 1.08-3.66, χ2 = 4.85 (1)), while IPV and depression were not. Events representing HIV transmission potential, where there was biological evidence of condomless sex at a visit with a detectable plasma viral load, were observed at 2% of visits. The high prevalence of IPV and association between alcohol use and sexual risk suggest the need for monitoring and support for these conditions as part of comprehensive HIV care for women.

中文翻译：

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肯尼亚内罗毕血清不一致夫妇中 HIV 阳性妇女的心理社会因素、无安全套性行为和可检测的病毒载量。

这项针对血清不一致夫妇中 HIV 阳性的肯尼亚妇女的前瞻性研究检查了社会心理因素、病毒抑制和无安全套性行为之间的关系。每年对参与者进行酒精使用障碍和亲密伴侣暴力 (IPV) 筛查，每 6 个月筛查一次抑郁症状。前列腺特异性抗原 (PSA) 检测被用作无安全套性行为的标志物。共有 151 名参与者贡献了 349 人年的随访时间。有害/有害饮酒与在阴道分泌物中检测到 PSA 的风险增加有关（aRR 1.99，95%CI 1.08-3.66，χ2 = 4.85 (1)），而 IPV 和抑郁症则不然。在 2% 的就诊中观察到了代表 HIV 传播潜力的事件，即在可检测到血浆病毒载量的就诊中存在无安全套性行为的生物学证据。