The aim was to examine the association between the hypoxia-inducible factor-1α (HIF1A) gene and the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene polymorphisms and the endurance/power athlete status and relative aerobic capacity. Another goal of this study was to reveal the connection between GNB3, blood pressure (BP), body composition and body mass index (BMI). Two hundred thirty-eight people participated in this study: 148 elite athletes (men = 107, women = 41) and 90 controls (men = 51, women = 39). The athletes were divided into two groups: the power and the endurance athletes. BMI and body fat percentage (fat%) were calculated. Fifty of the athletes underwent an incremental treadmill test to exhaustion; BP was monitored before and after the test. There were differences in the genotype frequencies of HIF1A between the endurance and the control group (ProPro: 64% vs.79%, ProSer: 27% vs.19%, SerSer: 9% vs. 2%; p = .0351); in the allele prevalences among the three groups (Pro: 87% vs. 77% vs. 88%; Ser: 13% vs. 23% vs. 12%; p = .0103) and between the endurance and control group (p = .0049) as well. The GNB3 allele proportions differed in the three groups (C: 74% vs. 61% vs. 71%, T: 26% vs. 39% vs. 29%; p = .0436). There were no connections between the genotypes and the relative aerobic capacity and neither between GNB3 genotypes and BP, BMI and fat%. The connection of GNB3 T allele to the endurance performance still remained contradictable.

中文翻译：

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GNB3 rs5443、HIF1A rs11549465多态性、生理和功能特征之间缺乏关联

目的是检查缺氧诱导因子 1α (HIF1A) 基因和鸟嘌呤核苷酸结合蛋白 β 多肽 3 (GNB3) 基因多态性与耐力/爆发力运动员状态和相对有氧能力之间的关联。这项研究的另一个目标是揭示 GNB3、血压 (BP)、身体成分和体重指数 (BMI) 之间的联系。238 人参与了这项研究：148 名优秀运动员（男性 = 107，女性 = 41）和 90 名对照组（男性 = 51，女性 = 39）。运动员分为两组：力量型和耐力型运动员。计算BMI和体脂百分比(fat%)。50 名运动员进行了增量跑步机测试，直至精疲力竭；测试前后监测血压。耐力组和对照组之间 HIF1A 的基因型频率存在差异（ProPro：64% vs.79%，ProSer：27% vs.19%，SerSer：9% vs. 2%；p = .0351）；三组之间的等位基因流行率（Pro：87% vs. 77% vs. 88%；Ser：13% vs. 23% vs. 12%；p = .0103）以及耐力组和对照组之间（p = .0049）也是如此。GNB3 等位基因比例在三组中不同（C：74% vs. 61% vs. 71%，T：26% vs. 39% vs. 29%；p = .0436）。基因型与相对有氧能力之间没有联系，GNB3 基因型与 BP、BMI 和脂肪％之间也没有联系。GNB3 T 等位基因与耐力性能的联系仍然存在矛盾。87% 对 77% 对 88%；Ser：13% 对 23% 对 12%；p = .0103) 以及耐力组和对照组之间 (p = .0049)。GNB3 等位基因比例在三组中不同（C：74% vs. 61% vs. 71%，T：26% vs. 39% vs. 29%；p = .0436）。基因型与相对有氧能力之间没有联系，GNB3 基因型与 BP、BMI 和脂肪％之间也没有联系。GNB3 T 等位基因与耐力性能的联系仍然存在矛盾。87% 对 77% 对 88%；Ser：13% 对 23% 对 12%；p = .0103) 以及耐力组和对照组之间 (p = .0049)。GNB3 等位基因比例在三组中不同（C：74% vs. 61% vs. 71%，T：26% vs. 39% vs. 29%；p = .0436）。基因型与相对有氧能力之间没有联系，GNB3 基因型与 BP、BMI 和脂肪％之间也没有联系。GNB3 T 等位基因与耐力性能的联系仍然存在矛盾。