Understanding the mechanisms underpinning the response to acute stress is critical for determining how this can be modulated in both health and disease and across sexes. Stress can markedly alter the microbiome and gut‐brain axis signaling with the serotonergic system being particularly sensitive to acute stress. As the impact of acute stress on regional serotonergic dynamics in the gut‐brain axis and the contribution of the microbiome to this are poorly appreciated, we used microbiota‐deficient mice to assess whether the serotonergic response to acute stress exposure is microbiome dependent.

中文翻译：

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对急性应激暴露的肠脑轴血清素能反应是微生物组依赖性的。

了解支持对急性压力的反应的机制对于确定如何在健康和疾病以及跨性别中进行调节至关重要。压力可以显着改变微生物组和肠脑轴信号，血清素系统对急性压力特别敏感。由于急性压力对肠脑轴区域血清素能动力学的影响以及微生物组对此的贡献鲜为人知，我们使用微生物群缺陷的小鼠来评估对急性压力暴露的血清素能反应是否依赖于微生物组。