A novel pH‐responsive micellar nanoparticle based on poly(ethylene glycol)–polydimethylsiloxane–poly(ethylene glycol) triblock copolymer with benzoic imine linkage is reported. A new synthetic approach to produce the pH‐cleavable polymer that can self‐assemble into stable micellar nanoparticle is presented. Such nanoparticles are stable at physiological pH, but degrade at slightly acidic pH, making this system potentially suitable to exploit pH gradients in biological compartments. The precursors, intermediates, final polymers, and micellar nanoparticles are characterized in detail by various spectroscopic techniques, gel permeation chromatography, and particle size measurements.

中文翻译：

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pH响应胶束形成两亲性三嵌段共聚物

报道了一种新型的具有pH响应的胶束纳米粒子，该粒子基于具有苯甲酸亚胺键的聚（乙二醇）-聚二甲基硅氧烷-聚（乙二醇）三嵌段共聚物。提出了一种新的合成方法，以生产可自组装成稳定胶束纳米粒子的pH可裂解聚合物。这样的纳米颗粒在生理pH下是稳定的，但是在弱酸性pH下会降解，使得该系统潜在地适合于利用生物区室中的pH梯度。通过各种光谱技术，凝胶渗透色谱法和粒度测量，对前体，中间体，最终聚合物和胶束纳米颗粒进行了详细表征。