Sudden unexpected death in epilepsy (SUDEP) is a frequent cause of death in epilepsy. Respiratory dysfunction is implicated as a critical factor in SUDEP pathophysiology. Human studies have shown that electrical stimulation of the amygdala resulted in apnea, indicating that the amygdala has a role in respiration control. Unilateral amygdala stimulation resulted in immediate onset of respiratory dysfunction occurring only during nose breathing. In small numbers of patients, some but not all spontaneous seizures resulted in apnea occurring shortly after seizure spread to the amygdala. With this study we aimed to determine whether seizure onset or spread to the amygdala was necessary and sufficient to cause apnea.

中文翻译：

---

与癫痫发作相关的呼吸暂停与杏仁核癫痫发作传播之间存在不一致的联系

癫痫中的突然意外死亡 (SUDEP) 是癫痫中常见的死亡原因。呼吸功能障碍被认为是 SUDEP 病理生理学中的一个关键因素。人体研究表明，杏仁核的电刺激导致呼吸暂停，表明杏仁核在呼吸控制中起作用。单侧杏仁核刺激导致仅在鼻子呼吸时立即发生呼吸功能障碍。在少数患者中，一些但不是全部自发性癫痫发作导致在癫痫发作扩散到杏仁核后不久发生呼吸暂停。通过这项研究，我们旨在确定癫痫发作或扩散到杏仁核是否是导致呼吸暂停的必要和充分条件。