Although mortality rates have declined in recent years, the majority of cancers remain incurable and the medical challenge is evident. Recent progress in cancer genetics and genomics along with the identification of a novel generation of cancer hallmarks, that is, reprogramming of energy metabolism and evasion from immune surveillance, have led to the discovery of novel NF-κB-dependent cancer vulnerabilities. These discoveries have led to better patient stratification, and new drug combinations using cutting-edge therapies. This review aims to give an up-to-date view on the therapeutic potential of NF-κB transcription factors and the signaling pathways that control their activity in the new era of cancer therapy.

尽管近年来死亡率有所下降，但大多数癌症仍然无法治愈，医学挑战也很明显。癌症遗传学和基因组学的最新进展以及新一代癌症特征的识别，即能量代谢的重编程和逃避免疫监视，导致发现了新的 NF-κB 依赖性癌症脆弱性。这些发现导致了更好的患者分层，以及使用尖端疗法的新药物组合。本综述旨在对 NF-κB 转录因子的治疗潜力以及在癌症治疗新时代控制其活性的信号通路提供最新观点。