Human macrophage migration inhibition factor (MIF) is a protein with cytokine and chemokine properties that regulates a diverse range of physiological functions related to innate immunity and inflammation. Most research has focused on the role of MIF in different inflammatory diseases. D-dopachrome tautomerase (DDT), a different molecule with structural similarities to MIF, which shares receptors and biological functions, has recently been reported, but little is known about its roles and mechanisms. In this review, we sought to understand the similarities and differences between these molecules by summarizing what is known about their different structures, receptors and mechanisms regulating their expression and biological activities with an emphasis on immunological aspects.

中文翻译：

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巨噬细胞迁移抑制因子 (MIF) 家族的免疫调节：D-多巴色素互变异构酶 (DDT) 不是（总是）备用系统

人类巨噬细胞迁移抑制因子 (MIF) 是一种具有细胞因子和趋化因子特性的蛋白质，可调节与先天免疫和炎症相关的多种生理功能。大多数研究都集中在 MIF 在不同炎症性疾病中的作用。D-多巴色素互变异构酶 (DDT) 是一种与 MIF 结构相似的不同分子，具有受体和生物学功能，最近已有报道，但对其作用和机制知之甚少。在这篇综述中，我们试图通过总结关于这些分子的不同结构、受体和调节其表达和生物活性的机制的已知信息，重点是免疫学方面，来了解这些分子之间的异同。