The compound γ-terpineol, which presents potential as microbicide and anticancer drug, was incorporated in cholesterol Langmuir monolayers, pure or mixed with DPPC. The compound expands the monolayers at higher molecular areas, but condenses them at lower areas, indicating a structural molecular rearrangement of γ-terpineol at the-water interface upon compression. Such effect was confirmed with rheological, surface potential, Brewster angle microscopy and infrared data, which indicated, respectively, reduction of the compressional modulus of the lipid monolayer, decrease of the surface potential, formation of aggregates, and alteration of the trans/gauche conformers ratio for methylene groups. Distinctive effects were observed for cholesterol monolayers without or with the presence of DPPC. Such results may help understand how the interaction of γ-terpineol with lipidic surfaces is modulated by lipids able to mediate the packing state of biointerfaces.

中文翻译：

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单环单萜叔醇γ-松油醇对含有胆固醇的生物界面的影响。

化合物γ-萜品醇具有杀微生物剂和抗癌药的潜力，已被掺入胆固醇Langmuir单层膜中，可与DPPC混合或与之混合。该化合物在较高的分子区域使单分子层膨胀，但在较低的分子区域使它们缩合，表明γ-萜品醇在压缩后在水界面处发生结构分子重排。流变学，表面电势，布鲁斯特角显微镜和红外数据证实了这种作用，分别表明脂质单层的压缩模量降低，表面电势降低，聚集体形成以及反式/薄纱构象异构体的改变。亚甲基的比率。在不存在或存在DPPC的情况下，胆固醇单层具有明显的作用。