Abstract Isotopic analysis, together with size distribution analyses of platinum nanoparticles (Pt NPs) have been made by a multiple collector-ICP-mass spectrometer equipped with a high-time resolution data acquisition system (HTR-MC-ICP-MS). With the present system, time-integration efficiency of nearly 100% was achieved from up to four isotopic signals, enabling us to measure both the size and isotopic ratios from a single NP. Based on the 195Pt/194Pt ratios obtained from more than 1000 particles, the precisions of the 195Pt/194Pt ratio measurements on 30 nm, 50 nm, and 70 nm were approximately 40% (2SD), 20% (2SD), and 10% (2SD). These results were comparable to possible variations in the 195Pt/194Pt ratios estimated by counting statistics of the isotopic signals, suggesting that the isotopic ratio measurements could be achieved from transient signal events originating from NPs. The data obtained here demonstrated that the HTR-MC-ICP-MS technique can become a powerful tool to monitor the elemental/isotopic ratios from single NPs.

中文翻译：

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使用高时间分辨率多收集器 ICP-MS 对单个纳米颗粒中的铂进行同位素分析

摘要 同位素分析以及铂纳米粒子 (Pt NPs) 的尺寸分布分析已通过配备高时间分辨率数据采集系统 (HTR-MC-ICP-MS) 的多收集器-ICP-质谱仪进行。使用本系统，最多四个同位素信号实现了近 100% 的时间积分效率，使我们能够测量单个 NP 的大小和同位素比率。基于从 1000 多个粒子获得的 195Pt/194Pt 比率，30 nm、50 nm 和 70 nm 的 195Pt/194Pt 比率测量精度约为 40% (2SD)、20% (2SD) 和 10% （2SD）。这些结果与通过同位素信号的计数统计估计的 195Pt/194Pt 比率的可能变化相当，表明同位素比率测量可以从源自 NPs 的瞬态信号事件中实现。此处获得的数据表明，HTR-MC-ICP-MS 技术可以成为监测单个 NP 的元素/同位素比率的强大工具。