Hydatidosis is a zoonotic disease that commonly occurs in several places around the world, especially in the Middle East, due to infection by the larval stage of Echinococcus granulosus. This disease impacts an immense effect on the economic and public health of both humans and animals. Despite their effectiveness, the unacceptable side effects and progressive resistance to scolicidal agents may limit their use. According to their biopharmaceutical activity and benefits, numerous studies have reported that scorpion venom and its derivatives represent important resources for therapeutic applications. Therefore, this study was designed to investigate the in vitro scolicidal consequences of the crude venom of Androctonus crassicauda on E. granulosus. For this purpose, protoscolices from infected organs of camel containing hydatid cysts were collected, separated, and washed. The scolicidal impacts of three different concentrations of the crude venom (20, 50, and 100 µg/mL) were tested at different times of exposure (30, 60, 120, and 240 min). Particularly, eosin exclusion test was used to examine the viability of the protoscolices. The study results showed that the crude venom at 100 μg/mL destroys all protoscolices after 240 min incubation. Also, the scolicidal activity of venom increased significantly according to the time of exposure. In conclusion, the crude venom of A. crassicauda demonstrated high scolicidal activity in vitro against protoscolices of hydatid cysts in low concentration and short exposure time. However, the efficacy of scorpion venom remains to be evaluated in vivo for the treatment of hydatidosis in both humans and domesticated animals.

d虫病是一种人畜共患疾病，由于细粒棘球oc虫的幼虫期感染，通常在世界各地发生，特别是在中东。这种疾病对人类和动物的经济和公共健康产生巨大影响。尽管它们有效，但不可接受的副作用和对杀虫剂的逐步耐药性可能会限制其使用。根据它们的生物药学活性和益处，许多研究报告称，蝎毒及其衍生物是治疗应用的重要资源。因此，本研究旨在调查Androctonus crassicauda的粗毒对E. granulosus的体外杀伤作用。为此目的，收集，分离并洗涤来自含有骆驼科囊肿的骆驼的受感染器官的原黏膜。在不同的暴露时间（30、60、120和240分钟）测试了三种不同浓度的粗毒液（20、50和100 µg / mL）的杀伤力。特别地，曙红排除试验用于检查原黏膜的生存力。研究结果表明，孵育240分钟后，浓度为100μg/ mL的粗毒液破坏了所有原壳。而且，毒液的杀卵活性根据暴露时间而显着增加。总之，A。crassicauda的粗毒证明了在体外以低浓度和短暴露时间对against虫囊原虫的高杀卵活性。然而，蝎毒的功效尚待在体内评估，以用于治疗人和家畜中的hy虫病。