当前位置: X-MOL 学术Saudi J. Biol. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats
Saudi Journal of Biological Sciences ( IF 4.4 ) Pub Date : 2020-05-11 , DOI: 10.1016/j.sjbs.2020.05.009
Abdul Ahad , Mohammad Raish , Yousef A. Bin Jardan , Mohd Aftab Alam , Abdullah M. Al-Mohizea , Fahad I. Al-Jenoobi

The objective of this investigation was to study whether Nigella Sativa and Trigonella Foenum-graecum, could modulate the losartan pharmacodynamic (PD) and pharmacokinetic (PK) in experimental L-NAME induced hypertensive rats. For in vivo study, the systolic blood pressure (SBP) of rats was measured by the “tail-cuff system” after the treatment of rats with herb alone and herb + losartan in hypertensive rats. The SBP of rats treated with L-NAME + losartan also recorded. For the PK study, blood samples were obtained for up to 12 h to determine the concentrations of the drug, and various PK parameters were calculated. The data displayed that the SBP was significantly (p < 0.05) decreased in the rats when administered with L-NAME + N. Sativa or L-NAME + T. Foenum-graecum in contrast to the rats administered with L-NAME alone. A more prominent decline (p < 0.05) in SBP was detected in rats administered with L-NAME + N. Sativa + losartan and L-NAME + T. Foenum-graecum + losartan. In a PK study, higher losartan Cmax and AUC0-t were noted in rats treated with N. Sativa + losartan and T. Foenum-graecum + losartan, although the difference was not significant in contrast to the control group. This study proposed that the interaction between N. Sativa & losartan and T. Foenum-graecum & losartan could take place on concurrent administration; consequently, the dose of losartan may need to be accustomed when they are utilized simultaneously.



中文翻译:

Nigella SativaTrigonella Foenum-graecum与losartan在L-NAME诱发的高血压大鼠中的潜在药效和药代动力学相互作用

这项研究的目的是研究Nigella SativaTrigonella Foenum-graecum在实验性L-NAME诱发的高血压大鼠中是否可以调节氯沙坦的药效学(PD)和药代动力学(PK)。为了进行体内研究,在仅用草药和草药+氯沙坦治疗高血压大鼠后,通过“尾巴套系统”测量大鼠的收缩压(SBP)。还记录了用L-NAME +氯沙坦治疗的大鼠的SBP。对于PK研究,需要长达12小时的血液样本以确定药物的浓度,并计算了各种PK参数。数据显示,与L-NAME + N. Sativa或L-NAME + 一起使用时,大鼠的SBP明显降低(p <0.05)  与仅施用L-NAME的大鼠相反,T。Foenum-graecum。在使用L-NAME +苜蓿 +氯沙坦和L-NAME +  T. Foenum-graecum  +氯沙坦的大鼠中,SBP的下降更为显着(p <0.05)  。在一项PK研究中,在用N. Sativa  +氯沙坦和T. Foenum-graecum  +氯沙坦治疗的大鼠中观察到较高的losartan C max和AUC 0-t,尽管与对照组相比差异并不显着。这项研究表明,苜蓿和洛沙坦猪笼草T. Foenum-graecum之间的相互作用氯沙坦可以同时进行管理;因此,当同时使用氯沙坦时,可能需要习惯剂量。

更新日期:2020-05-11
down
wechat
bug