Whether ancestry drives molecular differences that underlie disparities in cancer incidence and outcome is poorly understood. In this issue of Cancer Cell, Carrot-Zhang et al., through a rigorous analytical framework, explore ancestry-specific patterns of molecular alterations in cancers and demonstrate the need for novel strategies to address this formidable challenge.

中文翻译：

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缩小差距：遗传先祖对肿瘤发生途径的影响。

祖先是否驱动了导致癌症发生率和结果差异的分子差异，人们对此知之甚少。在本期《癌细胞》中，Carrot-Zhang等人通过严格的分析框架探索了祖先特定分子在癌症中的分子变化模式，并证明了需要新颖的策略来应对这一严峻挑战。