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Evaluation of the frequency and diagnostic delay of primary immunodeficiency disorders among suspected patients based on the 10 warning sign criteria: A cross-sectional study in Iran.
Allergologia et Immunopathologia ( IF 1.8 ) Pub Date : 2020-05-11 , DOI: 10.1016/j.aller.2020.03.005
A Bahrami 1 , S Sayyahfar 2 , Z Soltani 1 , M Khodadost 3 , B Moazzami 4 , N Rezaei 4
Affiliation  

Introduction

The prevalence of undiagnosed primary immunodeficiency diseases is remarkably high and contributes to increasing the rate of morbidity and mortality among this group of patients.

Objective

To examine the 10 warning sign scoring system in patients suspected of primary immune deficiency and also estimate the diagnostic delay in patients with proven disease.

Methods

This descriptive cross-sectional study was carried out during the years 2015–2016 in Ali Asghar (AS) Clinic and Hospital. Two hundred patients with suspected primary immune deficiency disease were eligible for inclusion in the study. Multivariable logistic regression analysis was used to determine the relation between findings.

Results

In this study, the majority of suspected cases of immunodeficiency were males (57%) with a mean age of 3.33 ± 2.89 years. Twenty-one (10.5%) patients were diagnosed with immunodeficiency disease. The mean diagnostic delay among primary immune deficient patients was 2.05 ± 1.7 years. There was a significant relationship between having parental consanguinity (OR = 2.68, 95% CI: 1.07–6.70), allergies (OR = 5.03, 95% CI: 1.13–22.31), vaccine adverse effects (OR = 9.31, 95% CI: 1.24–69.96) and primary immune deficiency diagnosis. No association was observed between age (OR = 0.98, 95% CI: 0.84–1.14), gender (OR = 0.99, 95% CI: 0.39–2.47), immune deficiency scoring (OR = 0.68, 95% CI: 0.31–1.45) and primary immune deficiency diagnosis.

Conclusion

Ten warning sign scoring system is of less value to consider a patient suspected of having primary immune deficiency. There is a meaningful delay in diagnosis of primary immune deficiencies especially in antibody deficiency defects which seeks further upgrading of knowledge in physicians.



中文翻译:

根据 10 个警告标志标准评估疑似患者原发性免疫缺陷疾病的频率和诊断延迟:伊朗的一项横断面研究。

介绍

未确诊的原发性免疫缺陷疾病的患病率非常高,这导致该组患者的发病率和死亡率增加。

客观的

检查疑似原发性免疫缺陷患者的 10 个警告标志评分系统,并估计确诊疾病患者的诊断延迟。

方法

这项描述性横断面研究于 2015-2016 年在 Ali Asghar (AS) 诊所和医院进行。200 名疑似原发性免疫缺陷病患者符合纳入研究的条件。多变量逻辑回归分析用于确定结果之间的关系。

结果

在这项研究中,大多数疑似免疫缺陷病例是男性 (57%),平均年龄为 3.33 ± 2.89 岁。21 名 (10.5%) 患者被诊断出患有免疫缺陷疾病。原发性免疫缺陷患者的平均诊断延迟为 2.05 ± 1.7 年。父母血缘关系 (OR = 2.68, 95% CI: 1.07–6.70)、过敏 (OR = 5.03, 95% CI: 1.13–22.31)、疫苗不良反应 (OR = 9.31, 95% CI: 1.24–69.96)和原发性免疫缺陷诊断。在年龄(OR = 0.98, 95% CI: 0.84–1.14)、性别(OR = 0.99, 95% CI: 0.39–2.47)、免疫缺陷评分(OR = 0.68, 95% CI: 0.31–1.45)之间未观察到相关性)和原发性免疫缺陷诊断。

结论

十警告标志评分系统在考虑怀疑患有原发性免疫缺陷的患者时价值较小。原发性免疫缺陷的诊断存在有意义的延迟,尤其是抗体缺陷缺陷,这需要医生进一步提高知识水平。

更新日期:2020-05-11
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