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Research progress of biomarkers in early detection of chemotherapy-induced cardiotoxicity.
Heart Failure Reviews ( IF 4.6 ) Pub Date : 2020-05-11 , DOI: 10.1007/s10741-020-09948-6
Wanli Gai 1 , Jian An 1 , Zhixin Wang 1 , Xuebin Han 1 , Jianhui Geng 1 , Yunliang Liang 2 , Yanqing Guo 1
Affiliation  

With the advances of drug therapy, the prognosis of cancer patients has seen remarkable improvements, and cancer-related mortality has decreased significantly. However, the followed drug-related cardiotoxicity becomes a serious threat to patients' living quality and survival rate. Cardiovascular toxicity associated with some chemotherapy drugs is reversible and dose-dependent. If early identification is possible, early cardiovascular protection measures or adjustment of chemotherapy regimens can be taken to improve the prognosis of patients. Therefore, early prevention and monitoring of chemotherapy-related cardiotoxicity are critical for cancer patients and survivors. Among them, biomarkers are an important method for the early identification of myocardial injury.

中文翻译:

早期检测化疗所致心脏毒性的生物标志物研究进展[J].

随着药物治疗的进步,癌症患者的预后显着改善,癌症相关死亡率显着下降。然而,随之而来的药物相关心脏毒性已严重威胁到患者的生活质量和生存率。与某些化疗药物相关的心血管毒性是可逆的且具有剂量依赖性。如果能够早期识别,可以早期采取心血管保护措施或调整化疗方案,以改善患者的预后。因此,早期预防和监测化疗相关的心脏毒性对癌症患者和幸存者至关重要。其中,生物标志物是早期识别心肌损伤的重要方法。
更新日期:2020-05-11
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