BACKGROUND Albumin to fibrinogen ratio (AFR) play a crucial role in the progression and prognosis of many malignant tumors. This study aimed to comprehensively assess the diagnostic value of AFR as single markers or in combination with squamous cell carcinoma antigen (SCC-Ag), cancer antigen 125 (CA-125) in cervical cancer. METHODS A total of 323 cervical cancer inpatients, 143 patients with cervical intraepithelial neoplasia (CIN) and 317 healthy controls were analyzed. Differences in laboratory parameters and clinicopathological features were calculated using the Mann-Whitney U or Kruskal-Wallis H test. The receiver operating characteristic (ROC) curve was used to evaluate the predicted value of AFR, alone or combined with SCC-Ag, CA-125 for the diagnosis of cervical cancer. RESULTS The levels of AFR in patients with cervical cancer were significantly lower than those in the CIN patients and the control subjects. AFR were not only negatively correlated with the tumor stage, but also related to histology typing, lymph node metastasis, distant metastasis, depth of stromal infiltration, tumor size, and tumor stage; however, it was not associated with the blood group. AFR combined with SCC-Ag possessed a larger area under the curve (AUC; AUCAFR+SCC-Ag = 0.924, 95% confidence interval (CI) 0.900, 0.944) than AFR (P < 0.001), SCC-Ag (P < 0.001), or CA-125 (P < 0.001) did alone. CONCLUSIONS The pretreatment levels of AFR, alone or combined with SCC-Ag, CA-125 could improve the diagnostic efficiency of cervical cancer.

中文翻译：

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白蛋白与纤维蛋白原比值在宫颈癌中的诊断价值。

背景技术白蛋白与纤维蛋白原的比值（AFR）在许多恶性肿瘤的进展和预后中起着至关重要的作用。本研究旨在全面评估AFR作为单一标志物或与鳞状细胞癌抗原（SCC-Ag）、癌抗原125（CA-125）联合在宫颈癌中的诊断价值。方法对323例宫颈癌住院患者、143例宫颈上皮内瘤变（CIN）患者和317例健康对照进行分析。使用 Mann-Whitney U 或 Kruskal-Wallis H 检验计算实验室参数和临床病理学特征的差异。采用受试者工作特征(ROC)曲线评价AFR单独或联合SCC-Ag、CA-125对宫颈癌诊断的预测值。结果宫颈癌患者AFR水平明显低于CIN患者和对照组。AFR不仅与肿瘤分期呈负相关，而且与组织学分型、淋巴结转移、远处转移、间质浸润深度、肿瘤大小和肿瘤分期有关；然而，它与血型无关。AFR 联合 SCC-Ag 的曲线下面积 (AUC; AUCAFR+SCC-Ag = 0.924, 95% 置信区间 (CI) 0.900, 0.944) 比 AFR (P < 0.001)、SCC-Ag (P < 0.001) 更大) 或 CA-125 (P < 0.001) 单独进行。结论 AFR预处理水平单独或联合SCC-Ag、CA-125可提高宫颈癌的诊断效率。AFR不仅与肿瘤分期呈负相关，而且与组织学分型、淋巴结转移、远处转移、间质浸润深度、肿瘤大小和肿瘤分期有关；然而，它与血型无关。AFR 联合 SCC-Ag 的曲线下面积 (AUC; AUCAFR+SCC-Ag = 0.924, 95% 置信区间 (CI) 0.900, 0.944) 比 AFR (P < 0.001)、SCC-Ag (P < 0.001) 更大) 或 CA-125 (P < 0.001) 单独进行。结论 AFR预处理水平单独或联合SCC-Ag、CA-125可提高宫颈癌的诊断效率。AFR不仅与肿瘤分期呈负相关，而且与组织学分型、淋巴结转移、远处转移、间质浸润深度、肿瘤大小和肿瘤分期有关；然而，它与血型无关。AFR 联合 SCC-Ag 的曲线下面积 (AUC; AUCAFR+SCC-Ag = 0.924, 95% 置信区间 (CI) 0.900, 0.944) 比 AFR (P < 0.001)、SCC-Ag (P < 0.001) 更大) 或 CA-125 (P < 0.001) 单独进行。结论 AFR预处理水平单独或联合SCC-Ag、CA-125可提高宫颈癌的诊断效率。AFR 联合 SCC-Ag 的曲线下面积 (AUC; AUCAFR+SCC-Ag = 0.924, 95% 置信区间 (CI) 0.900, 0.944) 比 AFR (P < 0.001)、SCC-Ag (P < 0.001) 更大) 或 CA-125 (P < 0.001) 单独进行。结论 AFR预处理水平单独或联合SCC-Ag、CA-125可提高宫颈癌的诊断效率。AFR 联合 SCC-Ag 的曲线下面积 (AUC; AUCAFR+SCC-Ag = 0.924, 95% 置信区间 (CI) 0.900, 0.944) 比 AFR (P < 0.001)、SCC-Ag (P < 0.001) 更大) 或 CA-125 (P < 0.001) 单独进行。结论 AFR预处理水平单独或联合SCC-Ag、CA-125可提高宫颈癌的诊断效率。