Iseolides A-C (1-3), three new glycosylated macrolides, were identified from the culture extract of Streptomyces sp. DC4-5 isolated from a stony coral Dendrophyllia. Extensive analysis of one- and two-dimensional NMR data, coupled with MS/MS analytical data, revealed that iseolides are new congeners of 36-membered macrolides, PM100117 and PM100118, previously reported from a marine-derived Streptomyces. Iseolides showed potent antifungal activity against a plant pathogen Glomerella cingulata and human pathogens Candida albicans and Trichophyton rubrum with MIC in the range of 0.19-6.25 μg/mL.

中文翻译：

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Iseolides AC，抗真菌大环内酯类化合物，来自珊瑚链霉菌属的放线菌。

从链霉菌属的培养物提取物中鉴定出三个新的糖基化大环内酯类油酸伊索利特AC（1-3）。DC4-5从石质珊瑚树中分离出来。一维和二维NMR数据的广泛分析，再加上MS / MS分析数据，揭示了等位内酯是36元大环内酯类的新同类物，PM100117和PM100118，以前是从海洋衍生链霉菌中报道的。伊索利特显示对植物病原体格氏小球菌和人类病原体白色念珠菌和毛癣菌的有效抗真菌活性，MIC在0.19-6.25μg/ mL范围内。