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Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs
Nature Physics ( IF 19.6 ) Pub Date : 2020-05-11 , DOI: 10.1038/s41567-020-0894-9
A Erzberger 1, 2 , A Jacobo 1, 2 , A Dasgupta 1 , A J Hudspeth 1
Affiliation  

Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here, we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events—one mediated by biochemical signalling and the other by cellular mechanics—give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ.



中文翻译:

侧线感觉器官形态发生过程中的机械化学对称性破缺

生物细胞中普遍存在的主动调节对称性破缺是定向细胞运动和形态极化等现象的基础。在这里,我们研究了在机械感觉器官形成过程中,器官水平的极性模式是如何通过细胞水平的对称性破缺而出现的。结合理论、遗传扰动和体内成像,我们研究了斑马鱼侧线中流体运动传感器的发育和再生。我们发现两个相互作用的对称性破坏事件——一个由生化信号介导,另一个由细胞力学介导——引起细胞对的精确旋转,从而在受体器官中产生镜像对称的极性模式。

更新日期:2020-05-11
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