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The claustrum coordinates cortical slow-wave activity.
Nature Neuroscience ( IF 25.0 ) Pub Date : 2020-05-11 , DOI: 10.1038/s41593-020-0625-7
Kimiya Narikiyo 1, 2 , Rumiko Mizuguchi 1, 3 , Ayako Ajima 1, 2 , Momoko Shiozaki 1, 2, 4 , Hiroki Hamanaka 5, 6 , Joshua P Johansen 5, 7 , Kensaku Mori 1, 2 , Yoshihiro Yoshihara 1, 2
Affiliation  

During sleep and awake rest, the neocortex generates large-scale slow-wave (SW) activity. Here, we report that the claustrum coordinates neocortical SW generation. We established a transgenic mouse line that enabled the genetic interrogation of a subpopulation of claustral glutamatergic neurons. These neurons received inputs from and sent outputs to widespread neocortical areas. The claustral neuronal firings mostly correlated with cortical SW activity. In vitro optogenetic stimulation of the claustrum induced excitatory postsynaptic responses in most neocortical neurons, but elicited action potentials primarily in inhibitory interneurons. In vivo optogenetic stimulation induced a synchronized down-state featuring prolonged silencing of neural activity in all layers of many cortical areas, followed by a down-to-up state transition. In contrast, genetic ablation of claustral neurons attenuated SW activity in the frontal cortex. These results demonstrate a crucial role of claustral neurons in synchronizing inhibitory interneurons across wide cortical areas for the spatiotemporal coordination of SW activity.

中文翻译:

锁骨协调皮层慢波活动。

在睡眠和清醒休息期间,新皮质会产生大规模的慢波(SW)活动。在这里,我们报告锁骨协调新皮质SW生成。我们建立了一个转基因小鼠品系,该基因使能对clastral谷氨酸能神经元亚群进行基因询问。这些神经元从广泛的新皮层区域接收输入并将输出发送到新的皮层区域。clastral神经元放电大多与皮质SW活动相关。锁骨的体外光遗传刺激在大多数新皮层神经元中引起兴奋性突触后反应,但主要在抑制性中神经元中引起动作电位。体内光遗传学刺激诱导了同步下降状态,其特征是许多皮质区域的所有层中神经活动的沉默时间延长,随后是从上到下的状态转变。相反,clastral神经元的遗传消融减弱了额叶皮层的SW活性。这些结果表明clastral神经元在同步抑制跨整个皮层区域的interneurons的时空协调SW活动的关键作用。
更新日期:2020-05-11
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