The ability of eukaryotic parasites from the phylum Apicomplexa to cause devastating diseases is predicated upon their ability to maintain faithful and precise protein trafficking mechanisms. Their parasitic life cycle depends on the trafficking of effector proteins to the infected host cell, transport of proteins to several critical organelles required for survival, as well as transport of parasite and host proteins to the digestive organelles to generate the building blocks for parasite growth. Several recent studies have shed light on the molecular mechanisms parasites utilise to transform the infected host cells, transport proteins to essential metabolic organelles and for biogenesis of organelles required for continuation of their life cycle. Here, we review key pathways of protein transport originating and branching from the endoplasmic reticulum, focusing on the essential roles of chaperones in these processes. Further, we highlight key gaps in our knowledge that prevents us from building a holistic view of protein trafficking in these deadly human pathogens.

中文翻译：

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指挥交通：在疟疾寄生虫中伴侣蛋白介导的蛋白质运输。

来自尖顶线虫门的真核寄生虫引起毁灭性疾病的能力取决于它们保持忠实而精确的蛋白质运输机制的能力。它们的寄生生命周期取决于效应蛋白向受感染宿主细胞的运输，蛋白质向存活所必需的几个关键细胞器的运输以及寄生虫和宿主蛋白向消化细胞器的运输以产生寄生虫生长的基础。最近的一些研究揭示了寄生虫用来转化受感染宿主细胞，将蛋白质转运到必需的代谢细胞器以及维持其生命周期所需的细胞器的生物发生的分子机制。这里，我们回顾了蛋白质转运从内质网起源和分支的关键途径，重点研究了伴侣蛋白在这些过程中的重要作用。此外，我们强调了我们知识的主要差距，这些差距使我们无法对这些致命的人类病原体中的蛋白质运输建立全面的看法。