Lipid layers are considered among the first protective barriers of the human body against pollutants, e.g., skin, lung surfactant, or tear film. This makes it necessary to explore the physico-chemical bases underlying the interaction of pollutants and lipid layers. This work evaluates using a pool of surface-sensitive techniques, the impact of carbon black and fumed silica particles on the behavior of Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). The results show that the incorporation of particles into the lipid monolayers affects the surface pressure–area isotherm of the DPPC, modifying both the phase behavior and the collapse conditions. This is explained considering that particles occupy a part of the area available for lipid organization, which affects the lateral organization of the lipid molecules, and consequently the cohesion interactions within the monolayer. Furthermore, particles incorporation worsens the mechanical performance of lipid layers, which may impact negatively in different processes presenting biological relevance. The modification induced by the particles has been found to be dependent on their specific chemical nature. This work tries to shed light on some of the most fundamental physico-chemical bases governing the interaction of pollutants with lipid layers, which plays an essential role on the design of strategies for preventing the potential health hazards associated with pollution.

中文翻译：

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粒子与1,2-二棕榈酰基-Sn-甘油-磷酸三磷酸胆碱的Langmuir单分子层的相互作用：是化学物质吗？

脂质层被认为是人体抵御污染物（例如皮肤，肺表面活性剂或泪膜）的第一道屏障。这使得有必要探索构成污染物和脂质层相互作用的物理化学基础。这项工作使用一系列表面敏感技术评估了碳的影响 黑色和气相二氧化硅颗粒对1,2-二棕榈酰-sn-甘油-3-磷酸胆碱（DPPC）Langmuir单分子膜行为的影响。结果表明，脂质单层中掺入颗粒会影响DPPC的表面压力-面积等温线，从而改变相行为和塌陷条件。考虑到颗粒占据了脂质组织可用区域的一部分，这会影响脂质分子的侧向组织，进而影响单分子层内的内聚相互作用，因此对此进行了解释。此外，颗粒的掺入使脂质层的机械性能恶化，这可能在呈现生物学相关性的不同过程中产生负面影响。已经发现由颗粒引起的改性取决于它们的特定化学性质。