Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in the heart, but its function there is unclear. CFTR regulates an ATP release pore in many tissues, but the identity and regulatory mechanism of the pore are unknown. We investigated the role of CFTR in ATP release from primary cardiomyocytes and ventricular wall in vivo.

中文翻译：

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囊性纤维化跨膜电导调节剂依赖性碳酸氢盐进入通过线粒体信号传导和胱天蛋白酶激活，通过pannexin1控制大鼠心肌ATP释放。

囊性纤维化跨膜电导调节剂（CFTR）在心脏中表达，但其功能尚不清楚。CFTR调节许多组织中的ATP释放孔，但该孔的身份和调控机制尚不清楚。我们研究了CFTR在体内从原代心肌细胞和心室壁释放ATP中的作用。