BACKGROUND Epidemiological, pathological and radiological studies suggest that inflammatory demyelination in MS is an age-dependent process, and that the formation of focal inflammatory demyelinating lesions decreases with age. Gadolinium-enhancing lesions are a biomarker of inflammatory disease activity in MS, but little is known about the relation of age and gadolinium enhancement on cranial MRI scans in people with MS. In this study, we investigated the association of age and other risk factors with gadolinium enhancement on cranial MRI in a retrospective cross-sectional clinical MS cohort. METHODS In a cohort including 1543 people with CIS and MS, we investigated the association of the risk factors age, sex, disease course, immunomodulatory drug (IMD) treatment, and disability with gadolinium enhancement on cranial MRI scans using a binary logistic regression model. RESULTS Age was the most important factor associated with gadolinium enhancement, with the odds of gadolinium enhancement decreasing with advancing age. Participants with CIS had lower odds of gadolinium enhancement (odds ratio of 0.42, 95% confidence interval of 0.24-0.72 compared to RRMS). Sex, disease course and IMD treatment were not significantly associated with gadolinium enhancement in our cohort. CONCLUSIONS Our investigation shows that gadolinium enhancement is strongly associated with age. Since gadolinium enhancement is a marker of inflammatory disease activity, our findings suggest that inflammatory disease activity declines with age, and that IMD treatment may be more beneficial in younger and less useful in older people with MS.

中文翻译：

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在多发性硬化症的颅骨MRI上enhancement的增强与年龄有关。

背景技术流行病学，病理学和放射学研究表明，MS中的炎性脱髓鞘是一个年龄依赖性的过程，局灶性炎性脱髓鞘病变的形成随年龄而减少。MS增强病变是MS中炎症性疾病活动的生物标志物，但对于MS患者进行颅骨MRI扫描时年龄和g增强之间的关系知之甚少。在这项研究中，我们在回顾性横断面临床MS队列中研究了年龄和其他危险因素与增强对颅脑MRI的关系。方法在一个包括1543名CIS和MS患者的队列研究中，我们调查了年龄，性别，病程，免疫调节药物（IMD）治疗，二元逻辑回归模型在颅骨MRI扫描中使用with增强功能治疗残疾和残疾。结果年龄是与enhancement增强有关的最重要因素，with增强的几率随年龄的增长而降低。患有CIS的参与者of升高的几率较低（与RRMS相比，优势比为0.42，95％置信区间为0.24-0.72）。在我们的队列中，性别，病程和IMD治疗与g的增强没有显着相关。结论我们的研究表明g的增强与年龄密切相关。由于g的增强是炎性疾病活动的标志，因此我们的研究结果表明，炎性疾病活动随着年龄的增长而下降，