Cancer is the second leading cause of death after heart disease in the world and the third leading cause of death after heart disease and accidents in Iran. In general, cancer is a disorder of the rate of proliferation and cell differentiation that can occur in any tissue of the body and at any age and by invading healthy tissues may exacerbate the disease and eventually cause death. In a word, one of the most commonly used treatments for cancer is the use of chemotherapy. The drugs of the aforementioned chemotherapy are transported through the blood to cancer cells and all parts of the body. In addition to cancer cells, these drugs also have a detrimental effect on healthy cells, which can be seen as side effects. It is to note that they are temporary and can stop at the end of treatment. The subject behind this research is to propose super-twisting sliding mode control approach without chattering for mathematical model of cancer by immunotherapy with the aim of stabilizing the closed-loop system, as long as determining the optimal drug dose is taken into consideration as the innovation of this study to conclude which controller has the better performance in the presence of uncertainties and disturbances.

癌症是世界上仅次于心脏病的第二大死因，也是伊朗仅次于心脏病和事故的第三大死因。通常，癌症是可能在身体的任何组织中以及在任何年龄发生的增殖和细胞分化速率失调，并且通过侵袭健康组织可能使疾病恶化并最终导致死亡。简而言之，最常用的癌症治疗方法之一是使用化学疗法。上述化学疗法的药物通过血液输送到癌细胞和人体的各个部位。除了癌细胞之外，这些药物还对健康细胞产生有害作用，这可以看作是副作用。要注意的是，它们是暂时的，可以在治疗结束时停止。