The modification of implant devices with biocompatible coatings has become necessary as a consequence of premature loosening of prosthesis. This is caused mainly by chronic inflammation or allergies that are triggered by implant wear, production of abrasion particles, and/or release of metallic ions from the implantable device surface. Specific to the implant tissue destination, it could require coatings with specific features in order to provide optimal osseointegration. Pulsed laser deposition (PLD) became a well-known physical vapor deposition technology that has been successfully applied to a large variety of biocompatible inorganic coatings for biomedical prosthetic applications. Matrix assisted pulsed laser evaporation (MAPLE) is a PLD-derived technology used for depositions of thin organic material coatings. In an attempt to surpass solvent related difficulties, when different solvents are used for blending various organic materials, combinatorial MAPLE was proposed to grow thin hybrid coatings, assembled in a gradient of composition. We review herein the evolution of the laser technological process and capabilities of growing thin bio-coatings with emphasis on blended or multilayered biomimetic combinations. These can be used either as implant surfaces with enhanced bioactivity for accelerating orthopedic integration and tissue regeneration or combinatorial bio-platforms for cancer research.

中文翻译：

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组合激光技术获得的仿生涂层

由于假体的过早松动，必须对具有生物相容性涂层的植入装置进行改造。这主要是由植入物磨损，产生磨损颗粒和/或金属离子从可植入设备表面释放引起的慢性炎症或过敏引起的。特定于植入物组织目的地，可能需要具有特定功能的涂层才能提供最佳的骨整合。脉冲激光沉积（PLD）成为一种众所周知的物理气相沉积技术，已成功应用于生物医学假体应用的多种生物相容性无机涂层。基质辅助脉冲激光蒸发（MAPLE）是一种PLD衍生的技术，用于沉积薄有机材料涂层。为了克服与溶剂有关的困难，当使用不同的溶剂来混合各种有机材料时，提出了组合MAPLE来生长薄的混合涂料，以组合物的梯度进行组装。我们在此回顾激光技术工艺的发展以及生长薄生物涂层的能力，重点是混合或多层仿生组合。这些可以用作具有增强的生物活性的植入物表面，以加速整形外科手术的整合和组织再生，也可以用作用于癌症研究的组合生物平台。我们在这里回顾了激光技术过程的发展以及生长薄的生物涂层的能力，重点是混合或多层仿生组合。这些可以用作具有增强的生物活性的植入物表面，以加速整形外科手术的整合和组织再生，也可以用作用于癌症研究的组合生物平台。我们在此回顾激光技术工艺的发展以及生长薄生物涂层的能力，重点是混合或多层仿生组合。这些可以用作具有增强的生物活性的植入物表面，以加速整形外科手术的整合和组织再生，也可以用作用于癌症研究的组合生物平台。