当前位置: X-MOL 学术J. Heterocycl. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Convenient synthesis of functionalized thieno[2,3‐d]pyrimidine‐4‐ones and thieno[2,3‐b]pyridine‐4‐ones bearing a pyridine moiety with anticipated antioxidant activity
Journal of Heterocyclic Chemistry ( IF 2.4 ) Pub Date : 2020-05-08 , DOI: 10.1002/jhet.4002
Ahmed El‐Mekabaty 1 , Abd El‐Aziz S. Fouda 1 , Ibrahim E. I. Shaaban 1
Affiliation  

In the present study, ethyl 2‐amino‐4‐methyl‐5‐(pyridin‐2‐ylcarbamoyl)thiophene‐3‐carboxylate(2) has been achieved using the Gewald's methodology and served as a synthon for the synthesis of various derivatives of thieno[2,3‐d ]pyrimidine‐4‐one and thieno[2,3‐b ]pyridine‐4‐one bearing a pyridine moiety via its reactions with the convenient chemical reagents. The antioxidant performance has been tested using the ABTS method and the results disclosed that thienopyrimidinone 5 and thienopyridinones 18 and 19 have the most potent antioxidant efficiency with inhibition percentage at 84.41%, 80.95%, and 76.93%, respectively, compared with ascorbic acid as a reference drug.

中文翻译:

方便合成具有吡啶基部分并具有预期抗氧化活性的功能化噻吩并[2,3- [d]嘧啶-4-酮和噻吩并[2,3-b]吡啶-4-酮

在本研究中,使用Gewald方法获得了2-氨基-4-甲基-5-甲基(吡啶-2-基氨基甲酰基)噻吩-3-羧酸乙酯(2),并用作合成各种噻吩并[2,3 - d ]嘧啶-4-酮和噻吩并[2,3 - b ]吡啶-4-酮通过与方便的化学试剂反应而带有吡啶部分。使用ABTS方法测试了抗氧化剂的性能,结果表明,噻吩并嘧啶酮5和噻吩并吡啶并酮1819具有最强的抗氧化剂效率,与抗坏血酸作为抗氧化剂相比,其抑制百分比分别为84.41%,80.95%和76.93%。参考药物。
更新日期:2020-07-15
down
wechat
bug