Polycystic ovarian syndrome (PCOS) in reproductive-aged women is identified to be one of the endocrine disorders. This heterogeneous disorder is categorized through oligo-anovulation and hyperandrogenemia. National institutes of health and Rotterdam criterions were used to diagnose PCOS women. Type 2 Diabetes (T2D) is one of the complications in PCOS which is connected through insulin resistance (IR), which is a condition in which liver, muscles and fat infrequently respond to the hormones, and this leads to extreme IR and consequently leads to T2D disease. PCOS is inherited by the autosomal dominant mode of inheritance and may also with the different intricate patterns. Till now, many studies have been performed in PCOS with the genes identified by T2D and till now no studies have shown the similar genetic association and pathophysiology between both the diseases. So, the current review aims to investigate the genetic relation between PCOS and T2D and why both the diseases cannot be reverted. In this review, published data were screened with the T2D related genes and single nucleotide polymorphisms in PCOS women. The case-control, hospital-based and meta-analysis molecular studies disclosed both positive and negative connotations. Genetically, no relationship has been established between PCOS and T2D. Maximum studies have shown as PCOS women had developed T2D later in life because as a risk-factor, but none of the studies documented T2D women having developed PCOS as a risk factor. Apart from this, the disease PCOS is developed in women with reproductive age and T2D develops in both the men and women during adulthood. This review concludes as there is a genetic relation only in between PCOS and T2D, but not with T2D to PCOS and further it cannot be explicitly reverted from T2D to PCOS.

育龄妇女的多囊卵巢综合症（PCOS）被确定为内分泌疾病之一。这种异质性疾病通过无排卵和高雄激素血症进行分类。使用国家卫生研究院和鹿特丹的标准来诊断PCOS妇女。2型糖尿病（T2D）是PCOS的并发症之一，它是通过胰岛素抵抗（IR）连接的，胰岛素抵抗是肝脏，肌肉和脂肪很少对激素产生反应的疾病，这会导致极端的IR，从而导致T2D疾病。PCOS由常染色体显性遗传模式继承，也可能具有不同的复杂模式。直到现在，在PCOS中已经进行了许多由T2D鉴定的基因的研究，到目前为止，尚无研究显示两种疾病之间具有相似的遗传关联和病理生理学。因此，当前的综述旨在研究PCOS和T2D之间的遗传关系，以及两种疾病为何无法逆转的原因。在这篇综述中，使用PCOS妇女的T2D相关基因和单核苷酸多态性筛选了已发表的数据。病例对照，以医院为基础荟萃分析分子研究揭示了积极和消极的含义。从基因上讲，PCOS和T2D之间没有建立任何关系。大量研究表明，由于PCOS女性在以后的生活中会患T2D，因为这是一个危险因素，但是没有研究表明T2D女性已将PCOS作为危险因素。除此之外，PCOS病在育龄妇女中发展，成年男性和女性都在发展T2D。这篇综述的结论是，仅在PCOS和T2D之间存在遗传关系，而在T2D与PCOS之间不存在遗传关系，而且不能将其从T2D明确还原为PCOS。