The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong energy density and high palatability. Over the decade, the notion that the dietary fatty acids convey signaling cues to oro-gustatory system embrace profound ability in understanding its function along with its perception of dietary fats. In this review, recent developments in the field of oleogustus and its downstream signaling mechanism in taste bud cells are analyzed. Notably, we made a brief attempt to expose the possible negative modulator components that had the potential to modulate the distinctive fat signal transduction components and its oro-gustatory mechanism. This review is in-sighted to urge the scientific community to work towards that goal to establish the libraries comprising both chemical and natural fat taste modifiers that adhere to fat taste receptors and alters its gustatory sense to proficiently combat obesity-linked complications.

肥胖及其相关疾病（包括糖尿病和各种心血管疾病）的发病率持续上升。由于能量稳态在富含脂肪的食物摄入和体重调节中起着重要作用，因此它以其强大的能量密度和高适口性而成为人们普遍关注的主题。在过去的十年中，饮食脂肪酸将信号提示传达给口-味觉系统的观念具有深刻的理解其饮食脂肪功能的能力。在这篇综述中，分析了香菇的最新发展及其在味蕾细胞中的下游信号传导机制。值得注意的是 我们做了短暂的尝试，以揭示可能的负调控因子成分，这些成分可能会调节独特的脂肪信号转导成分及其口味机制。这次审查是有见地的，以敦促科学界朝着实现这一目标的方向努力，以建立包含化学和天然脂肪味道改良剂的文库，这些文物与脂肪味道受体结合并改变其味觉以有效地对抗肥胖相关的并发症。