当前位置: X-MOL 学术Invertebr. Neurosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Features of behavioral changes underlying conditioned taste aversion in the pond snail Lymnaea stagnalis.
Invertebrate Neuroscience Pub Date : 2020-07-23 , DOI: 10.1007/s10158-020-00241-7
Junko Nakai , Yuki Totani , Satoshi Kojima , Manabu Sakakibara , Etsuro Ito

Conditioned taste aversion (CTA) in the freshwater pulmonate Lymnaea stagnalis can be formed by presenting ten pairings of sucrose as the conditioned stimulus (CS) and KCl as the unconditioned stimulus (US). The CTA is consolidated to long-term memory (LTM) lasting longer than a month. In the present study, we examined the time course of protein synthesis-dependent period during the consolidation of Lymnaea CTA to LTM by pharmacological inhibition of transcription or translation. The robustness for CTA–LTM was then examined by extinction trials, i.e., repeated presentations of the CS alone. Furthermore, we evaluated the effects of the interstimulus interval (ISI) between the presentation of the CS and US. Our findings indicated that the protein synthesis-dependent period coincides with the CTA training. Repeated presentations of the CS alone after establishment of CTA did not extinguish the CTA, demonstrating the robustness of the CTA–LTM. The ISI ranged from 10 s to a few minutes, and there was no inverted U-shaped function between the ISI and the conditioned response (i.e., suppression of feeding). Thus, CTA still formed even when the presentation of the US was delayed. These features of Lymnaea CTA complement the knowledge for mammalian CTA.

中文翻译:

池塘蜗牛Lymnaea stagnalis中条件性厌恶行为的行为变化特征。

可以通过提供十对蔗糖作为条件刺激物(CS)和KCl作为无条件刺激物(US)来形成淡水肺部的剑尾草内生条件性厌恶(CTA )。CTA已整合到持续超过一个月的长期记忆(LTM)。在本研究中,我们检查了Lymnaea巩固过程中蛋白质合成依赖期的时间过程通过药理学抑制转录或翻译将CTA转化为LTM。然后,通过消光试验(即单独重复CS演示)检查了CTA-LTM的稳健性。此外,我们评估了CS和US表现之间的间质间隔(ISI)的影响。我们的发现表明,蛋白质合成依赖期与CTA训练相吻合。建立CTA后,仅CS的反复演示并不能消除CTA,证明了CTA-LTM的强大功能。ISI的范围从10 s到几分钟,并且在ISI和条件响应(即抑制进食)之间没有倒U型功能。因此,即使延迟美国的出演,CTA仍会形成。Ly科的这些特征 CTA补充了哺乳动物CTA的知识。
更新日期:2020-07-23
down
wechat
bug