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Introducing New Conjugated Quantum Dots for Photothermal Therapy in Biological Applications
Plasmonics ( IF 3 ) Pub Date : 2020-05-08 , DOI: 10.1007/s11468-020-01171-1
M. Dolatyari , F. Alidoust Aghdam , G. Rostami , A. Rostami , I. S. Amiri

It is well-known that near-infrared (NIR) light sources are appropriate to ablate benign tumor irreversibly using heat treatment even in deep tissues. The laser light penetration into the skin in these wavelengths is deep (3–5 mm). Applying new stable materials for emitting NIR wavelengths in tumor positions can help cancer treatment. In this paper, synthesis of the conjugated core-multishell Ag/SiO2/Ag and Au/SiO2/Au quantum dots (QDs) with indocyanine green (ICG) is done and their theoretical and experimental absorptions and emissions in the NIR region are investigated. Thus, heat generation (high-resolution medical imaging capabilities) and emission enhancement are explained and described based on the FRET model for the proposed core-multishell QDs and it is shown that Ag/SiO2/Ag with ICG presents 4 times higher emission rate versus ICG alone in NIR region. Also, because of the plasmon hybridization and also resonance light penetration enhancement, the temperature in tissues increases that is useful for photothermal therapy and NIR high-resolution medical imaging for deep tissues. As an alternative application, these nanoparticles with amazing features are used as a heat source in cancer treatment for shallow and deep tissues. Finally, it is shown that Ag/SiO2/Ag QDs are the best solution for this purpose.



中文翻译:

在生物应用中引入用于光热疗法的新型共轭量子点

众所周知,即使在深部组织中,近红外(NIR)光源也适用于通过热处理不可逆地消融良性肿瘤。在这些波长下,激光穿透皮肤的深度很深(3-5毫米)。应用新的稳定材料在肿瘤位置发射NIR波长可以帮助癌症治疗。本文用吲哚菁绿(ICG)合成了共轭核-多壳Ag / SiO 2 / Ag和Au / SiO 2 / Au量子点(QDs),并在理论和实验上对NIR区域进行了吸收和发射。调查。因此,基于提出的核-多壳量子点的FRET模型,对热量产生(高分辨率医学成像能力)和发射增强进行了说明和描述,结果表明Ag / SiO在NIR区域,使用ICG的2 / Ag的发射速率是仅使用ICG的4倍。同样,由于等离激元杂交以及共振光穿透增强,组织中的温度升高,这对于深层组织的光热疗法和NIR高分辨率医学成像很有用。作为替代应用,这些具有惊人功能的纳米颗粒被用作浅层和深层组织癌症治疗的热源。最后,表明Ag / SiO 2 / Ag QDs是用于此目的的最佳解决方案。

更新日期:2020-05-08
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