Aquaporins (AQPs) are a family of transmembrane water channel proteins distributed in various human tissues. Recent studies revealed that AQPs play important roles in cancer biology. Few studies have documented the relationship between the prognosis, stage, and histological grade of uterine endometrioid carcinoma, with AQP expression. Hence, the present study aimed to investigate this relationship between uterine endometrioid carcinoma and AQP expression. We retrospectively reviewed records of the patients who underwent surgery for uterine body cancer between 1990 and 2010 at the National Defense Medical College Hospital, Saitama, Japan. In 241 cases of endometrioid carcinoma, we immunohistochemically examined the expression of AQP 1, 2, 3, 4, and 5, and their relationship with clinicopathological parameters and the patients' prognosis. We investigated the relationship between the clinicopathological parameters and AQP3 expression, and found that as the FIGO stage and histological grade progressed, the percentage of AQP3 expression tends to decrease. Furthermore, we analyzed progression-free survival/overall survival (PFS/OS) using the log-rank test, and found that the AQP3-positive group had a better prognosis than AQP3-negative group (PFS: P < 0.001, OS: P = 0.002, respectively). Using Cox's univariate proportional hazard model, we revealed that AQP3 had a low hazard ratio. However, according to Cox's multivariate proportional hazard model, AQP3 was not an independent prognostic factor. Among the endometrioid carcinoma patients, the AQP3-positive group was associated with early stage and lower grade compared to the AQP3-negative group. Therefore, AQP3 has the potential to serve as a predictor of prognosis, although further investigation is necessary to elucidate the biological mechanism of AQP3 in endometrioid carcinoma.

中文翻译：

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水通道蛋白3在子宫内膜样癌中的表达与早期和低度相关。

水通道蛋白（AQP）是分布在各种人体组织中的跨膜水通道蛋白家族。最近的研究表明，AQP在癌症生物学中起着重要作用。很少有研究记录子宫内膜样癌的预后，分期和组织学分级与AQP表达之间的关系。因此，本研究旨在研究子宫内膜样癌与AQP表达之间的这种关系。我们回顾性回顾了1990年至2010年之间在日本Japan玉县国防医学院附属医院接受子宫体癌手术的患者的记录。在241例子宫内膜样癌中，我们用免疫组织化学方法检测了AQP 1、2、3、4和5的表达及其与临床病理参数和患者预后的关系。我们研究了临床病理参数与AQP3表达之间的关系，发现随着FIGO分期和组织学分级的发展，AQP3表达的百分比趋于下降。此外，我们使用对数秩检验分析了无进展生存期/总生存期（PFS / OS），发现AQP3阳性组的预后比AQP3阴性组更好（PFS：P <0.001，OS：P分别为0.002）。使用Cox的单变量比例风险模型，我们发现AQP3的风险比很低。但是，根据Cox的多元比例风险模型，AQP3不是独立的预后因素。在子宫内膜样癌患者中，与AQP3阴性组相比，AQP3阳性组与早期和较低等级相关。因此，