RNA fulfills a crucial regulatory role in cells by folding into a complex RNA structure. To date, a chemical compound, dimethyl sulfate (DMS), has been developed to probe the RNA structure at the transcriptome level effectively. We proposed a database, RSVdb (https://taolab.nwafu.edu.cn/rsvdb/), for the browsing and visualization of transcriptome RNA structures. RSVdb, including 626 225 RNAs with validated DMS reactivity from 178 samples in eight species, supports four main functions: information retrieval, research overview, structure prediction and resource download. Users can search for species, studies, transcripts and genes of interest; browse the quality control of sequencing data and statistical charts of RNA structure information; preview and perform online prediction of RNA structures in silico and under DMS restraint of different experimental treatments and download RNA structure data for species and studies. Together, RSVdb provides a reference for RNA structure and will support future research on the function of RNA structure at the transcriptome level.

中文翻译：

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RSVdb：转录组 RNA 结构的综合数据库。

RNA 通过折叠成复杂的 RNA 结构在细胞中发挥关键的调节作用。迄今为止，已开发出一种化合物硫酸二甲酯 (DMS) 来有效地在转录组水平上探测 RNA 结构。我们提出了一个数据库 RSVdb (https://taolab.nwafu.edu.cn/rsvdb/)，用于转录组 RNA 结构的浏览和可视化。RSVdb 包括来自 8 个物种的 178 个样本的 626 225 条经验证具有 DMS 反应性的 RNA，支持四个主要功能：信息检索、研究概述、结构预测和资源下载。用户可以搜索感兴趣的物种、研究、转录本和基因；浏览测序数据的质量控制和RNA结构信息的统计图表；在不同实验处理的 DMS 约束下预览和在线预测 RNA 结构，并下载物种和研究的 RNA 结构数据。RSVdb 共同为 RNA 结构提供了参考，并将支持未来在转录组水平上对 RNA 结构功能的研究。