Macrophages are key immune cells that reside in almost all tissues of the body, where they exert pleiotropic functions in homeostasis and disease. Development and identity of macrophages in each organ are governed by tissue-dependent signaling pathways and transcription factors that ultimately define specific tissue-resident macrophage phenotypes and functions. In recent years, nuclear receptors, a class of ligand-activated transcription factors, have been found to play important roles in macrophage specification in several tissues. Nuclear receptors are thus important targets for therapies aimed at controlling the numbers and functions of tissue-resident macrophages. This review outlines current knowledge about the critical roles of nuclear receptors in tissue-resident macrophage development, specification, and maintenance.

中文翻译：

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核受体对组织驻留巨噬细胞身份的分子控制。

巨噬细胞是存在于身体几乎所有组织中的关键免疫细胞，它们在体内平衡和疾病中发挥多效功能。每个器官中巨噬细胞的发育和身份受组织依赖性信号通路和转录因子的控制，这些信号通路和转录因子最终定义了特定的组织驻留巨噬细胞表型和功能。近年来，已发现核受体，一类配体激活的转录因子，在多种组织的巨噬细胞特化中发挥重要作用。因此，核受体是旨在控制组织驻留巨噬细胞数量和功能的治疗的重要目标。本综述概述了目前关于核受体在组织驻留巨噬细胞发育、规范和维持中的关键作用的知识。