Aspergillus fumigatus can cause a wide range of diseases, from hypersensitivity to invasive infection. Invasive disease usually occurs in severely immunocompromised patients with deep and prolonged neutropenia. It is a less well-recognized complication in critically ill patients without traditional risk factors. We describe a case of early invasive pulmonary aspergillosis (IPA) secondary to Legionella pneumophila serogroup 1 pneumonia in a patient on an intensive care unit (ICU). In addition to commonly accepted risk factors for IPA in ICU patients, we hypothesis that L. pneumophilia pneumonia could enhance this type of infection. We also reviewed all published cases of coinfection with L. pneumophila and A. fumigatus to assess whether Legionnaires’ disease could be a risk factor for IPA.

烟曲霉可引起多种疾病，从超敏反应到侵入性感染。侵袭性疾病通常发生在严重的免疫功能低下的中性粒细胞减少症患者。在没有传统危险因素的危重患者中，这是一种不太为人所知的并发症。我们描述了重症监护病房（ICU）患者继发于军团菌嗜肺军团血清型1肺炎的早期侵袭性肺曲霉病（IPA ）。除了在ICU患者中普遍接受的IPA危险因素外，我们假设L. pneumophilia肺炎可以增强这种感染。我们还回顾了所有发表的肺炎链球菌和烟曲霉共感染病例。 评估退伍军人病是否可能是IPA的危险因素。