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Aggregation-Induced Emission Active Polyacrylates via Cu-Mediated Reversible Deactivation Radical Polymerization with Bioimaging Applications
ACS Macro Letters ( IF 5.8 ) Pub Date : 2020-05-08 , DOI: 10.1021/acsmacrolett.0c00281
Congkai Ma 1 , Ting Han 2, 3 , Miaomiao Kang 2 , Evelina Liarou 1 , Alan M Wemyss 1 , Spyridon Efstathiou 1 , Ben Zhong Tang 2, 3 , David Haddleton 1
Affiliation  

The introduction of aggregation-induced emission (AIE) moieties into polymers results in smart materials with AIE characteristics, expanding their scope of applications. Herein, well-defined polymers with controlled molecular weight, low dispersity, and high end-group fidelity are produced via copper(0)-mediated reversible-deactivation radical polymerizations (Cu(0)-RDRPs). An AIE-containing initiator tetraphenylethene bromoisobutyrate (TPEBIB) has been synthesized, fully characterized, and utilized for the construction of different polyacrylate homopolymers and block copolymers bearing the TPE group with a range of molecular weights and architectures. All of the polymers exhibited AIE behavior. Notably, the hydrophobic TPE-poly(tert-butyl acrylate) (TPE-PtBA)-containing block copolymers are transformed to TPE-poly(acrylic acid) (TPE-PAA)-based amphiphilic copolymers by facile deprotection, enabling pH-tunable self-assembly in aqueous media to give fluorescent nanoparticles with various sizes. The low cytotoxicity, high specificity, and excellent photostability render them promising candidates as lysosome-specific probes in biological imaging applications.

中文翻译:

通过 Cu 介导的可逆失活自由基聚合与生物成像应用的聚集诱导发射活性聚丙烯酸酯

将聚集诱导发射 (AIE) 部分引入聚合物中可产生具有 AIE 特性的智能材料,从而扩大了其应用范围。在此,通过铜(0)介导的可逆失活自由基聚合(Cu(0)-RDRPs)生产具有可控分子量、低分散性和高端基保真度的定义明确的聚合物。已经合成了一种含有 AIE 的引发剂四苯基乙烯溴异丁酸酯 (TPEBIB),并对其进行了充分表征,并用于构建具有不同分子量和结构的具有 TPE 基团的不同聚丙烯酸酯均聚物和嵌段共聚物。所有聚合物都表现出 AIE 行为。值得注意的是,疏水性 TPE-聚(丙烯酸丁酯)(TPE-P t含 BA) 的嵌段共聚物通过简单的脱保护转化为基于 TPE-聚丙烯酸 (TPE-PAA) 的两亲共聚物,从而在水性介质中实现 pH 可调的自组装,从而得到各种尺寸的荧光纳米粒子。低细胞毒性、高特异性和出色的光稳定性使它们成为生物成像应用中溶酶体特异性探针的有希望的候选者。
更新日期:2020-05-08
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