Aedes aegypti is the primary mosquito vector of dengue, yellow fever, Zika and chikungunya. Current strategies to control Ae. aegypti rely heavily on insecticide interventions. Pyrethroids are a major class of insecticides used for mosquito control because of their fast acting, highly insecticidal activities and low mammalian toxicity. However, Ae. aegypti populations around the world have begun to develop resistance to pyrethroids. So far, more than a dozen mutations in the sodium channel gene have been reported to be associated with pyrethroid resistance in Ae. aegypti. Co‐occurrence of resistance‐associated mutations is common in pyrethroid‐resistant Ae. aegypti populations. As global use of pyrethroids in mosquito control continues, new pyrethroid‐resistant mutations keep emerging. In this microreview, we compile pyrethroid resistance‐associated mutations in Ae. aegypti in a chronological order, as they were reported, and summarize findings from functional evaluation of these mutations in an in vitro sodium channel expression system. We hope that the information will be useful for tracing possible evolution of pyrethroid resistance in this important human disease vector, in addition to the development of methods for global monitoring and management of pyrethroid resistance in Ae. aegypti.

中文翻译：

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与埃及伊蚊拟除虫菊酯耐药性相关的钠通道突变的年表。

埃及伊蚊是登革热、黄热病、寨卡病毒和基孔肯雅热的主要蚊媒。当前控制Ae 的策略。埃及伊蚊严重依赖杀虫剂干预措施。拟除虫菊酯是用于控制蚊子的一类主要杀虫剂，因为其起效快、杀虫活性高且对哺乳动物的毒性低。然而，艾埃. 世界各地的埃及种群已开始对拟除虫菊酯产生抗药性。迄今为止，已有十多个钠通道基因突变被报道与伊蚊的拟除虫菊酯抗性相关。埃及伊蚊。抗性相关突变同时出现在拟除虫菊酯抗性伊蚊中很常见。埃及伊蚊种群。随着全球继续使用拟除虫菊酯来控制蚊子，新的拟除虫菊酯抗性突变不断出现。在这篇微综述中，我们编译了AE中与拟除虫菊酯抗性相关的突变。按报道的时间顺序对埃及伊蚊进行了研究，并总结了体外钠通道表达系统中这些突变的功能评估结果。我们希望这些信息除了有助于开发全球监测和管理伊蚊拟除虫菊酯抗性的方法外，还有助于追踪这一重要人类疾病媒介中拟除虫菊酯抗性的可能进化。埃及伊蚊。