Surfactants are one of the important ingredients of cosmetics. However, their penetration and penetration‐promoting behavior in the skin has not been well understood. Aiming to explore the surfactant penetration in skin, a novel fluorescent surfactant F‐C16, based on sodium fluorescein, was synthesized in this paper. F‐C16 has a fluorescence maxima (λ_em) of around 530 nm, and its fluorescence increased with the polarity of solvent. It possesses good emulsifying properties and low cytotoxicity. Hence, it can be used as a quickly detected indicator for surfactants in cosmetics. As demonstrated by this fluorescent surfactant, it was found that the surfactants can penetrate well into skin and cells. It seems that surfactants in cosmetics can enter the cells and reach the dermal layer of skin.

中文翻译：

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荧光表面活性剂的合成与表征，用于研究化妆品表面活性剂在皮肤上的渗透性

表面活性剂是化妆品的重要成分之一。但是，人们对它们在皮肤中的渗透和促进渗透的行为还没有很好的了解。为了探索表面活性剂在皮肤中的渗透，本文合成了一种基于荧光素钠的新型荧光表面活性剂F-C16。F-C16具有荧光最大值（λ _EM）的530nm附近，并且其荧光与溶剂的极性增加。它具有良好的乳化性能和低细胞毒性。因此，它可用作化妆品中表面活性剂的快速检测指示剂。如该荧光表面活性剂所证明的，发现表面活性剂可以很好地渗透到皮肤和细胞中。化妆品中的表面活性剂似乎可以进入细胞并到达皮肤的真皮层。