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Single unit and beta oscillatory activities in subthalamic nucleus are modulated during visual choice preference
European Journal of Neroscience ( IF 3.4 ) Pub Date : 2020-05-07 , DOI: 10.1111/ejn.14750
Tameem M Al-Ozzi 1, 2, 3 , Luis F Botero-Posada 4 , Adriana L Lopez Rios 4 , William D Hutchison 1, 2, 3, 4, 5
Affiliation  

Parkinson's disease is a neurodegenerative disease affecting the supply of dopamine to basal ganglia nuclei, leading to pathological beta band (13–35 Hz) oscillations in the subthalamic nucleus (STN). STN and beta activity are recognized in motoric functions but their role in cognitive functions remains elusive. We examined single unit and beta local field potential (LFP) activity in the STN during a visual choice preference task in PD patients (n = 12) undergoing deep brain stimulation surgery. Patients viewed 2 of 5 possible animal picture‐pairs and were instructed to choose their favorite (“fav”) picture by clicking the left or right mouse key. A block of trials consisted of 50–75 picture‐pair presentations. Single unit histograms and LFP spectrograms were aligned to picture presentation and point of decision for pairs that included the fav and non‐fav pictures, respectively. A total of 58 neurons from 26 blocks of trials were analyzed. Thirty of 58 neurons showed a selective change in spiking activity 0.20–0.65 s to fav picture presentation, which preceded the shortest recorded reaction time (=0.7 s), and 17/58 neurons showed no significant response in our task. Beta LFP significantly desynchronized in response to fav but not non‐fav pictures in all trials, and in 14/26 blocks of trials, the desynchronization was followed by a “beta burst” and ramp‐up to baseline activity. Neurons with choice preference responses were found throughout the dorsoventral extent of the STN. STN single units and beta activity are modulated during visual choice preference, and this suggests a role for STN beta activity in cognitive processing.

中文翻译:

在视觉选择偏好过程中,调节丘脑底核中的单个单位和β振荡活动

帕金森氏病是一种神经退行性疾病,影响多巴胺向基底神经节核的供应,导致丘脑底核(STN)发生病理性β波段(13–35 Hz)振荡。STN和β的活动在运动功能中被公认,但是它们在认知功能中的作用仍然难以捉摸。我们 在进行深度脑刺激手术的PD患者(n = 12)的视觉选择偏好任务期间,检查了STN中的单个单位和β局部场电位(LFP)活动。患者查看了5对可能的动物图片对中的2对,并被指示选择他们最喜欢的动物(“收藏夹””)图片,方法是单击鼠标左键或右键。一组试验由50-75张图片对演示文稿组成。将单个单位直方图和LFP频谱图与图片表示和决策点对齐,以分别包含收藏图片和非收藏夹图片对。共分析了来自26个试验块的58个神经元。58个神经元中有30个显示出尖峰活动的选择性变化,从fav图片呈现开始到出现记录的最短反应时间(= 0.7 s)之前,其fav图片呈现时间为0.20-0.65 s,而17/58个神经元在我们的任务中没有显示出明显的反应。Beta LFP响应于收藏夹而显着失步,但不是非收藏夹在所有试验中以及在14/26块试验中的照片中,去同步之后是“ beta爆发”,并逐渐增加到基线活动。在STN的整个腹背范围内都发现了具有选择偏好反应的神经元。STN单个单元和beta活性在视觉选择偏好中受到调节,这表明STN beta活性在认知过程中的作用。
更新日期:2020-05-07
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