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The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs
Phytochemistry Reviews ( IF 7.7 ) Pub Date : 2020-05-07 , DOI: 10.1007/s11101-020-09675-8
Lucie Cahlíková , Ippei Kawano , Martina Řezáčová , Gerald Blunden , Daniela Hulcová , Radim Havelek

Plants of the Amaryllidaceae family, have a wide distribution through both tropical and sub-tropical regions of the world. They have also a long and notable place in the history of traditional and Western medicine. Amaryllidaceae alkaloids are a structurally diverse group of plant metabolites with a wide range of biological properties including antimalarial, antitumor, antimicrobial, antiviral, enzyme inhibitory, antioxidant, anticonvulsant and antifungal activities. Among them, the haemanthamine-type alkaloids, which have the 5,10b-ethanophenanthridine skeleton as the core structure, represented by haemanthamine and haemanthidine, have received considerable attention, since they have been reported to possess antitumor properties. The present review aims to summarize comprehensively the research that has been published on the Amaryllidaceae alkaloids haemanthamine and haemanthidine.



中文翻译:

金缕梅科生物碱类樟脑胺,半胱氨酸及其半合成衍生物可作为潜在药物

石蒜科的植物在世界的热带和亚热带地区都有广泛的分布。它们在传统和西方医学的历史上也有着悠久而显着的地位。石蒜科生物碱是一组结构多样的植物代谢产物,具有广泛的生物学特性,包括抗疟疾,抗肿瘤,抗微生物,抗病毒,酶抑制,抗氧化剂,抗惊厥和抗真菌活性。其中,以5,10b-乙撑菲啶骨架为核心的以山梨糖胺和山梨糖胺为代表的山梨糖胺型生物碱,由于据报道具有抗肿瘤特性,因此受到了广泛的关注。

更新日期:2020-05-07
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