Substituting small molecule drugs with abundant and easily affordable ions may have positive effects on the way countless disease treatments are approached. The interest in strontium cation in bone therapies soared in the wake of the success of strontium ranelate in the treatment of osteoporosis. A new method for producing thin strontium-containing hydroxyapatite (Sr-HA, Ca₉Sr(PO₄)₆(OH)₂) films as coatings that render bioinert titanium implant bioactive is reported here. The method is based on the combination of a mechanochemical synthesis of Sr-HA targets and their deposition in form of thin films on top of titanium with the use of laser ablation at low pressure. The films were 1–2 μm in thickness and their formation was studied at different temperatures, including 25, 300, and 500 °C. Highly crystalline Sr-HA target transformed during pulsed laser deposition to a fully amorphous film, whose degree of long-range order recovered with temperature. Particle edges became somewhat sharper and surface roughness moderately increased with temperature, but the (Ca+Sr)/P atomic ratio, which increased 1.5 times during the film formation, remained approximately constant at different temperatures. Despite the mostly amorphous structure of the coatings, their affinity for capturing atmospheric carbon dioxide and accommodating it as carbonate ions that replace both phosphates and hydroxyls of HA was confirmed in an X-ray photoelectron spectroscopic analysis. As the film deposition temperature increased, the lattice voids got reduced in concentration and the structure gradually “closed,” becoming more compact and entailing a linear increase in microhardness with temperature, by 0.03 GPa/°C for the entire 25–500 °C range. Biocompatibility and bioactivity of Sr-HA thin films deposited on titanium were confirmed in an interaction with dental pulp stem cells, suggesting that these coatings, regardless of the processing temperature, may be viable candidates for the surface components of metallic bone implants.

用丰富且容易负担得起的离子代替小分子药物可能会对无数疾病治疗的方式产生积极影响。随着雷奈酸锶在骨质疏松症治疗中的成功，对骨治疗中锶阳离子的兴趣激增。一种制备含锶稀羟基磷灰石（Sr-HA，Ca ₉ Sr（PO ₄）₆（OH）_{2的新方法}）报道了具有涂层的薄膜，这些涂层使生物惰性钛植入物具有生物活性。该方法是基于机械化学合成Sr-HA靶标及其在低压下使用激光烧蚀在钛膜上以薄膜形式沉积的组合。膜的厚度为1-2μm，并在包括25、300和500°C在内的不同温度下研究了膜的形成。高度结晶的Sr-HA靶在脉冲激光沉积过程中转变为完全非晶的膜，其远距离有序度随温度恢复。颗粒边缘变得有些锋利，并且表面粗糙度随温度适度增加，但是（Ca + Sr）/ P原子比在成膜过程中增加了1.5倍，在不同温度下几乎保持恒定。尽管涂层大部分为非晶结构，但它们在捕获大气二氧化碳并将其作为取代HA的磷酸根和羟基的碳酸根离子容纳时的亲和力在X射线光电子能谱分析中得到了证实。随着膜沉积温度的升高，晶格空隙的浓度降低，结构逐渐“闭合”，变得更致密，并且随着温度的升高，显微硬度随温度线性增加，在整个25–500°C范围内增加0.03 GPa /°C。 。通过与牙髓干细胞的相互作用证实了沉积在钛上的Sr-HA薄膜的生物相容性和生物活性，这表明这些涂层，无论处理温度如何，都可能是金属骨植入物表面成分的可行候选物。它们在X射线光电子能谱分析中证实了它们对捕获大气中二氧化碳并将其作为取代HA的磷酸根和羟基的碳酸根离子容纳的亲和力。随着膜沉积温度的升高，晶格空隙的浓度降低，结构逐渐“闭合”，变得更致密，并且随着温度的升高，显微硬度随温度线性增加，在整个25–500°C范围内增加0.03 GPa /°C。 。通过与牙髓干细胞的相互作用证实了沉积在钛上的Sr-HA薄膜的生物相容性和生物活性，这表明这些涂层，无论处理温度如何，都可能是金属骨植入物表面成分的可行候选物。它们在X射线光电子能谱分析中证实了它们对捕获大气中二氧化碳并将其作为取代HA的磷酸根和羟基的碳酸根离子容纳的亲和力。随着膜沉积温度的升高，晶格空隙的浓度降低，结构逐渐“闭合”，变得更致密，并且随着温度的升高，显微硬度随温度线性增加，在整个25–500°C范围内增加0.03 GPa /°C。 。通过与牙髓干细胞的相互作用证实了沉积在钛上的Sr-HA薄膜的生物相容性和生物活性，这表明这些涂层，无论处理温度如何，都可能是金属骨植入物表面成分的可行候选物。