Polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC) hydrogels containing various CMC concentration of 2 to 10 wt% are prepared using cyclic freezing/thawing and subsequent γ-ray irradiation to evaluate the effect of CMC content on cell growth rate of the hydrogels. A 3-D porous network structure is successfully formed via physical and chemical crosslinking. The pore size and the metronidazole drug release rate of the PVA/CMC hydrogels increase with raising the CMC concentration from 2 to 10 wt%, however, the structural integrity is severely damaged. The highest compressive strength of 99.2 ± 9.6 kPa and the fastest cell growth determined by scratch assay and enzyme-linked immunosorbent assay are observed for the irradiated PVA/6 wt% CMC hydrogels, indicating that they are highly suitable for wound dressing requiring fast regeneration.

中文翻译：

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CMC浓度对PVA / CMC水凝胶细胞生长行为的影响

使用循环冷冻/融化和随后的γ射线辐照来制备含有2至10wt％的各种CMC浓度的聚乙烯醇（PVA）/羧甲基纤维素（CMC）水凝胶，以评估CMC含量对水凝胶细胞生长速率的影响。通过成功形成了3-D多孔网络结构物理和化学交联。PVA / CMC水凝胶的孔径和甲硝唑药物释放速率随CMC浓度从2 wt％增加到10 wt％而增加，但是，结构完整性受到严重破坏。对于经辐照的PVA / 6 wt％CMC水凝胶，观察到的最高抗压强度为99.2±9.6 kPa，通过刮擦试验和酶联免疫吸附试验确定的最快细胞生长，表明它们非常适合需要快速再生的伤口敷料。