Enantioselective chromatography is nowadays a reliable tool for single enantiomer production from a racemate. The recovery of the distomer by racemization and recycling is a promising method to tackle the 50% yield constraint and to increase the productivity. In this paper three process configurations are compared. The production of enantiopure mandelic acid and methionine enantiomers exploiting different enzymes for racemization are evaluated as part of different chromatographic process configurations. First, the benefits of conventional simulated moving bed (SMB) chromatography in contrast to a single column batch separation unit are assessed in integrated configurations. Then, a concept of coupling the racemization with a simpler three-zone SMB unit, where one regeneration zone is removed, is evaluated.

如今，对映选择性色谱是从外消旋体生产单个对映异构体的可靠工具。通过外消旋和再循环回收异构体是解决50％产量限制并提高生产率的有前途的方法。本文比较了三种工艺配置。作为不同色谱工艺配置的一部分，对利用不同酶进行消旋的对映体纯扁桃酸和蛋氨酸对映体的生产进行了评估。首先，在集成配置中评估了传统模拟移动床（SMB）色谱与单塔批量分离装置相比的优势。然后，评估了将消旋作用与更简单的三区域SMB单元（其中去除了一个再生区域）耦合的概念。