After the integrative storage of associated signals, a signal induces the recollection of its associated signal, or the other way around. This associative memory is essential to associative thinking, logical reasoning, imagination and computation. In terms of cellular mechanisms underlying associative memory, new mutual synapse innervations are formed among those coactivated neurons, so that they are recruited to be associative memory cells or associative memory neurons. These associative memory cells receive new synapse innervations alongside innate synapse inputs and encode signals carried by these inputs. We proposed to examine microRNAs as initiative factors for recruiting new synapse innervations and associative memory cells. In a mouse model of associative memory characterized as the reciprocal retrieval of associated whisker and odor signals, barrel and piriform cortical neurons gain their ability to encode whisker and odorant signals based on the newly formed synapse innervations between these coactivated cortices besides innate synapse inputs. miRNA-324 and miRNA-133a are required for recruiting these new synapse innervations and associative memory cells as well as sufficient for facilitating their recruitments, but not for innate synapse inputs. Therefore, the coactivation of sensory cortices through microRNA as initiative factor to recruit new mutual synapse innervations and associative memory cells for associative memory.

中文翻译：

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miRNA-324 / -133a对于在共激活的感觉皮层中募集新的突触神经和相关的记忆细胞至关重要。

在关联信号的集成存储之后，信号会引发其关联信号的回收，或者反过来。这种联想记忆对于联想思维，逻辑推理，想象力和计算至关重要。就联想记忆的细胞机制而言，在这些共激活的神经元之间形成了新的相互突触神经，因此它们被募集为联想记忆细胞或联想记忆神经元。这些关联存储单元与先天突触输入一起接收新的突触神经，并对这些输入所携带的信号进行编码。我们建议检查microRNA作为招募新的突触神经支配和相关的记忆细胞的主动因素。在以关联的晶须和气味信号的相互检索为特征的联想记忆的小鼠模型中，桶形和梨状皮质神经元基于先天突触输入之外在这些共激活的皮质之间新形成的突触神经支配，获得了编码晶须和气味信号的能力。miRNA-324和miRNA-133a是募集这些新的突触神经支配和关联记忆细胞所必需的，并且足以促进其募集，但对于先天突触输入却不足够。因此，通过microRNA的感觉皮层的共激活作为主动因素，以募集新的相互突触神经支配和联想记忆细胞用于联想记忆。除了先天突触输入外，桶状和梨状皮质神经元还基于这些共激活皮层之间新形成的突触神经支配，获得了对晶须和气味信号进行编码的能力。miRNA-324和miRNA-133a是募集这些新的突触神经支配和关联记忆细胞所必需的，并且足以促进其募集，但对于先天突触输入却不足够。因此，通过microRNA的感觉皮层共激活作为主动因素，以募集新的相互突触神经支配和联想记忆细胞用于联想记忆。除了先天突触输入外，桶状和梨状皮质神经元还基于这些共激活皮层之间新形成的突触神经支配，获得了对晶须和气味信号进行编码的能力。miRNA-324和miRNA-133a是募集这些新的突触神经支配和关联记忆细胞所必需的，并且足以促进其募集，但对于先天突触输入却不足够。因此，通过microRNA的感觉皮层共激活作为主动因素，以募集新的相互突触神经支配和联想记忆细胞用于联想记忆。但不适用于先天突触输入。因此，通过microRNA的感觉皮层的共激活作为主动因素，以募集新的相互突触神经支配和联想记忆细胞用于联想记忆。但不适用于先天突触输入。因此，通过microRNA的感觉皮层的共激活作为主动因素，以募集新的相互突触神经支配和联想记忆细胞用于联想记忆。