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Alkaloids including two rare variecolortides from the fungus Aspergillus ruber
Tetrahedron ( IF 2.1 ) Pub Date : 2020-05-06 , DOI: 10.1016/j.tet.2020.131258
Tizhuang Shan , Wei Jiang , Xin Liu , Chaojie Wang , Shuang Gao , Pengcheng Yan , Biyun Sun , Li Miao

Three new alkaloids, namely, (−)-(S)-variecolortide D (1a), (+)-(R)-variecolortide D (1b) and brevicompanine I (3), along with three known alkaloids (2, 4 and 5) were isolated from Aspergillus ruber WH4-1. Variecolortide D (1) is a racemic natural product composed of anthraquinone and isoechinulin alkaloid, separation of 1 by chiral HPLC, provided two optically pure enantioners (1a and 1b). The structures of all compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature. 2 showed weak inhibitory activity against the production of NO in RAW264.7 cells stimulated by lipopolysaccharide (LPS), with inhibitory rate of 53.2 ± 3.8% at 30 μM.



中文翻译:

生物碱,包括两种来自曲霉曲霉的罕见变色菌

三个新的生物碱,即( - ) - (小号)-variecolortide d(1A),(+) - ([R)-variecolortide d(1B)和brevicompanine I(3),以及三个已知生物碱(245)从曲霉WH4-1分离。Variecolortide D(1)是一种由蒽醌和异纤连蛋白生物碱组成的外消旋体天然产物,通过手性HPLC分离1,提供了两个光学纯的对映体(1a1b)。所有化合物的结构都通过对其光谱数据的广泛分析以及与文献的比较来确定。2呈弱的抑制活性对在RAW264.7细胞产生NO的刺激由脂多糖(LPS),具有53.2±3.8%抑制率在30  μ M.

更新日期:2020-05-06
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